{"id":"W4386209764","doi":"10.1093/brain/awad249","title":"Hypomyelination, hypodontia and craniofacial abnormalities in a <i>Polr3b</i> mouse model of leukodystrophy","year":2023,"lang":"en","type":"article","venue":"Brain","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Children's Hospital; Montreal Neurological Institute and Hospital; McGill University; Université de Montréal; Montreal Clinical Research Institute; McGill University Health Centre","funders":"Canadian Institutes of Health Research; University College London; Fonds de Recherche du Québec - Santé; Multiple Sclerosis Society of Canada; Children's Hospital Foundation; Faculty of Medicine, McGill University; Stowers Institute for Medical Research; McGill University; Faculty of Medicine and Health, University of Sydney; Northwestern University; National Institute of Dental and Craniofacial Research; University of Pennsylvania","keywords":"Biology; Leukodystrophy; Molecular biology; Western blot; Pathology; Genetics; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005479199,0.001031627,0.0005317828,0.00154872,0.0005734245,0.0007355946,0.0006612471,0.001503,0.003602286],"category_scores_gemma":[0.0001807165,0.0006101982,0.0008211336,0.0004724298,0.0008661192,0.0004769994,0.0004585681,0.002256127,0.001267496],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005696429,"about_ca_system_score_gemma":0.0004058167,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001194499,"about_ca_topic_score_gemma":0.001992684,"domain_scores_codex":[0.9992331,0.0001138888,0.0001113012,0.0002028193,0.0002168202,0.000122123],"domain_scores_gemma":[0.9995267,0.00004831763,0.0001690565,0.00005132575,0.00003881979,0.0001657492],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002878651,0.0001933596,0.0002172023,0.0000428808,0.00001224563,0.0003878009,0.0000579869,0.00009549363,0.9970781,0.0003877903,0.0001661767,0.001073146],"study_design_scores_gemma":[0.0002523859,0.002147636,0.007513576,0.00007869246,0.0001017567,0.004274291,0.0001837511,0.002123687,0.9700659,0.0003723014,0.01284808,0.00003795189],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9740838,0.001983424,0.0109314,0.0007669686,0.0001767382,0.0003408655,0.004902175,0.0009685392,0.005846149],"genre_scores_gemma":[0.9455994,0.002977768,0.01252836,0.00052081,0.00005728855,0.0009021245,0.004694718,0.0004199056,0.03229962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003602286,"threshold_uncertainty_score":0.01205087,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01212485558348695,"score_gpt":0.2360392784097169,"score_spread":0.22391442282623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}