{"id":"W4386209832","doi":"10.1016/j.virusres.2023.199211","title":"Coronavirus 2′-O-methyltransferase: A promising therapeutic target","year":2023,"lang":"en","type":"review","venue":"Virus Research","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Infection and Immunity; National Institute of Allergy and Infectious Diseases; National Institutes of Health; University of Texas System","keywords":"Biology; Coronavirus; Methylation; RNA; Pandemic; Viral replication; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Virology; Coronavirus disease 2019 (COVID-19); Coronaviridae; Epigenetics; Computational biology; Genetics; Virus; DNA; Gene; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.003267023,0.0006199846,0.001954692,0.00127676,0.0006572431,0.0001299577,0.001258164,0.001231367,0.004258203],"category_scores_gemma":[0.0004499624,0.0004738506,0.0007361799,0.001176494,0.0007474208,0.0000661839,0.0003820994,0.003535865,0.05202624],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003231324,"about_ca_system_score_gemma":0.001176074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003417912,"about_ca_topic_score_gemma":0.00005205137,"domain_scores_codex":[0.9913018,0.005092221,0.0008999067,0.0008924826,0.0002394541,0.001574144],"domain_scores_gemma":[0.9960963,0.002513352,0.0001241223,0.0009743454,0.0002273357,0.0000645502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002684522,0.0001630255,3.555452e-7,0.005587573,0.001177479,0.0000833679,0.0002059048,6.585198e-8,0.006551923,0.0002884076,0.0084588,0.9772146],"study_design_scores_gemma":[0.00038401,0.00038431,0.000002294125,0.005675455,0.0001585162,0.000127557,0.00007790382,2.726903e-7,0.003165532,0.000130187,0.9894361,0.0004578481],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0000305708,0.994084,0.00001949932,0.00003791373,0.0009819149,0.001761873,0.0002964383,0.0002808429,0.002506972],"genre_scores_gemma":[0.00003281024,0.935599,0.00001364928,0.00002974802,0.00009667976,0.0004739034,0.0003911436,0.0002102827,0.0631528],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9809773,"threshold_uncertainty_score":0.9997713,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4811417152456675,"score_gpt":0.5240330741256122,"score_spread":0.04289135887994472,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}