{"id":"W4386209832","doi":"10.1016/j.virusres.2023.199211","title":"Coronavirus 2′-O-methyltransferase: A promising therapeutic target","year":2023,"lang":"en","type":"review","venue":"Virus Research","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Infection and Immunity; National Institute of Allergy and Infectious Diseases; National Institutes of Health; University of Texas System","keywords":"Biology; Coronavirus; Methylation; RNA; Pandemic; Viral replication; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Virology; Coronavirus disease 2019 (COVID-19); Coronaviridae; Epigenetics; Computational biology; Genetics; Virus; DNA; Gene; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004427086,0.0006457489,0.0008791466,0.00102014,0.0002018446,0.0007784505,0.0006362628,0.001133185,0.003333705],"category_scores_gemma":[0.0004544706,0.0001997998,0.0003695667,0.0008784579,0.0003144584,0.001204262,0.0005072482,0.002224021,0.002195991],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004951561,"about_ca_system_score_gemma":0.0007432377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005573544,"about_ca_topic_score_gemma":0.001113908,"domain_scores_codex":[0.9998953,0.00001875758,0.00001261709,0.0000199475,0.00003631333,0.00001697561],"domain_scores_gemma":[0.9998504,0.00005747513,0.00001865473,0.000004996315,0.00004573092,0.00002259824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001136863,0.00007189571,0.0001250703,0.007931959,0.00006155844,0.0001972039,0.00004017943,0.0003769299,0.004091821,0.004311154,0.05367063,0.9290078],"study_design_scores_gemma":[0.00001805559,0.0000887131,0.0002931926,0.001103209,0.00003955587,0.0005688689,0.00002459518,0.00007233526,0.0004965786,0.001435359,0.9958496,0.000009944632],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001471171,0.9972932,0.0001616255,0.0006346593,0.0005538171,0.000005071511,0.00002411484,0.0000121391,0.001168309],"genre_scores_gemma":[0.0008685568,0.9969044,0.00024525,0.0005190987,0.0003394613,0.000008541758,0.00005124229,0.000002482976,0.001060883],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003333705,"threshold_uncertainty_score":0.01115239,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4811417152456675,"score_gpt":0.5240330741256122,"score_spread":0.04289135887994472,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}