{"id":"W4386212191","doi":"10.1172/jci.insight.166713","title":"Cardiac gene therapy treats diabetic cardiomyopathy and lowers blood glucose","year":2023,"lang":"en","type":"article","venue":"JCI Insight","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Nutrition, Metabolism and Diabetes","funders":"National Institute of General Medical Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institute on Aging; National Institutes of Health","keywords":"Diabetic cardiomyopathy; Internal medicine; GLUT4; Medicine; Endocrinology; Cardiomyopathy; Diabetes mellitus; Ejection fraction; Cardiac function curve; Downregulation and upregulation; Glucose transporter; Heart failure; Insulin; Cardiology; Chemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001405156,0.0001780915,0.0004318953,0.0001849903,0.00008225016,0.00002626441,0.00003983906,0.00009659075,0.00009575217],"category_scores_gemma":[0.00008044417,0.0001369171,0.0001456075,0.0004288765,0.00007493538,0.00005576705,0.00002883372,0.0001028507,0.0002393893],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000233427,"about_ca_system_score_gemma":0.00005508728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002331087,"about_ca_topic_score_gemma":3.316172e-7,"domain_scores_codex":[0.9989625,0.00005137352,0.0001708966,0.0002966712,0.0002307575,0.0002878347],"domain_scores_gemma":[0.9992334,0.0001183342,0.0000337113,0.0003428353,0.00005272068,0.0002189979],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002877538,0.000385532,0.3424071,0.0001440428,0.001320094,0.0004608386,0.002104206,0.000006314928,0.5912461,0.0001789303,0.01655091,0.04490816],"study_design_scores_gemma":[0.007173876,0.001129292,0.4114656,0.00009874467,0.000685198,0.00003542932,0.000267803,0.0001514993,0.4151858,0.0001864758,0.1631593,0.0004610271],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9749349,0.008180525,0.000002879425,0.0003894882,0.0005000623,0.0003023823,0.00001539347,0.0002610695,0.01541335],"genre_scores_gemma":[0.9900905,0.005540329,0.00008448312,0.0006479633,0.0003671435,0.00006227539,0.00006539429,0.0000356929,0.003106236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1760603,"threshold_uncertainty_score":0.5583317,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01813318953197174,"score_gpt":0.2410001106063474,"score_spread":0.2228669210743757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}