{"id":"W4386212191","doi":"10.1172/jci.insight.166713","title":"Cardiac gene therapy treats diabetic cardiomyopathy and lowers blood glucose","year":2023,"lang":"en","type":"article","venue":"JCI Insight","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Nutrition, Metabolism and Diabetes","funders":"National Institute of General Medical Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institute on Aging; National Institutes of Health","keywords":"Diabetic cardiomyopathy; Internal medicine; GLUT4; Medicine; Endocrinology; Cardiomyopathy; Diabetes mellitus; Ejection fraction; Cardiac function curve; Downregulation and upregulation; Glucose transporter; Heart failure; Insulin; Cardiology; Chemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001612163,0.0002975619,0.000352036,0.0003909326,0.0001591793,0.0004140547,0.0002395669,0.0003578069,0.001448196],"category_scores_gemma":[0.0001303522,0.0000759432,0.0001731461,0.0001751006,0.000298057,0.0002109219,0.0002239141,0.001060849,0.0003667072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002311049,"about_ca_system_score_gemma":0.0002006117,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002574143,"about_ca_topic_score_gemma":0.0003537558,"domain_scores_codex":[0.9999284,0.00001247593,0.000004195434,0.00000934914,0.00002650815,0.00001912087],"domain_scores_gemma":[0.9999473,0.000007545035,0.00001526196,0.000006154426,0.000007258959,0.00001643456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0012908,0.001028133,0.001365148,0.0005146519,0.0000824338,0.0005362824,0.0001020412,0.0004941502,0.8228583,0.00566507,0.00765688,0.1584061],"study_design_scores_gemma":[0.002079961,0.007256345,0.02350967,0.0005639185,0.0005430738,0.006330913,0.0003003363,0.005815876,0.7131655,0.007404596,0.232958,0.00007169678],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.861842,0.07315491,0.02180427,0.0106984,0.002277361,0.0001661779,0.0004678137,0.00108056,0.02850862],"genre_scores_gemma":[0.9222364,0.04996137,0.01217076,0.002978438,0.0007812029,0.0001253915,0.000504446,0.0001329296,0.01110904],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001448196,"threshold_uncertainty_score":0.004844666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01813318953197174,"score_gpt":0.2410001106063474,"score_spread":0.2228669210743757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}