{"id":"W4386213354","doi":"10.1371/journal.pgen.1010903","title":"Genetic enhancers of partial PLK1 inhibition reveal hypersensitivity to kinetochore perturbations","year":2023,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Cancer Research Society","keywords":"PLK1; Biology; Centromere; Kinetochore; Mitosis; Cell biology; Cytokinesis; Genetics; Cell cycle; Cell division; Chromosome; Gene; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008099101,0.0001527976,0.0001618851,0.0001011583,0.00006554237,0.00001410953,0.0001095557,0.0001501658,0.00001091836],"category_scores_gemma":[0.00009301495,0.0001667957,0.00009024375,0.0002972774,0.00006141326,0.00000215927,0.0001421345,0.00006801833,0.00005882621],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001931526,"about_ca_system_score_gemma":0.00007715672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005413279,"about_ca_topic_score_gemma":0.00003972242,"domain_scores_codex":[0.9988746,0.00005098144,0.0002564537,0.0003422079,0.0001915951,0.0002841637],"domain_scores_gemma":[0.9992529,0.00001464257,0.0000717734,0.0003775939,0.0001638015,0.0001192686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002887263,0.00005743104,0.0008415487,0.00002851326,0.00004129261,0.000003236561,0.0001560242,0.002028217,0.9927434,0.00001282049,0.002821577,0.001237076],"study_design_scores_gemma":[0.0002499066,0.000281279,0.004465565,0.00002480457,0.00004680741,0.000005909826,0.00008875933,0.00248493,0.9883186,0.00003240599,0.003797635,0.0002034034],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972623,0.0001370981,0.001442648,0.0001796498,0.0001312263,0.000331974,0.0001112107,0.00002791009,0.0003760087],"genre_scores_gemma":[0.996731,0.0002591661,0.001689394,0.0002673653,0.0003449596,0.00004378192,0.0002322252,0.00003388005,0.0003981943],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004424797,"threshold_uncertainty_score":0.6801732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01488639140184535,"score_gpt":0.2434686557515058,"score_spread":0.2285822643496604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}