{"id":"W4386213354","doi":"10.1371/journal.pgen.1010903","title":"Genetic enhancers of partial PLK1 inhibition reveal hypersensitivity to kinetochore perturbations","year":2023,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Cancer Research Society","keywords":"PLK1; Biology; Centromere; Kinetochore; Mitosis; Cell biology; Cytokinesis; Genetics; Cell cycle; Cell division; Chromosome; Gene; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001233715,0.0005865088,0.0003694163,0.0005268019,0.0001669623,0.0003251682,0.0004649561,0.0004880697,0.003541024],"category_scores_gemma":[0.0001336845,0.0003210476,0.0003965837,0.0003827331,0.0004584466,0.0001595393,0.0004427559,0.0009074088,0.0006843305],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004680253,"about_ca_system_score_gemma":0.0002984107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001198333,"about_ca_topic_score_gemma":0.001736783,"domain_scores_codex":[0.999728,0.00002638109,0.00003439555,0.00007800559,0.00007358067,0.00005958556],"domain_scores_gemma":[0.9996407,0.00009919824,0.0001298191,0.00003812052,0.00001162881,0.00008057171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007211194,0.00002599756,0.00008228596,0.00002254719,0.000006871208,0.00008484037,0.000007555547,0.0002109379,0.9986083,0.0001621959,0.00004323592,0.0006731072],"study_design_scores_gemma":[0.00002054729,0.0001498796,0.003645038,0.00000767215,0.00002060714,0.0003130712,0.00002473855,0.001619811,0.9920177,0.00007981932,0.00209145,0.000009541717],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853182,0.0008671935,0.00692451,0.0001536753,0.00006443535,0.00007847388,0.002624075,0.0005494855,0.003419955],"genre_scores_gemma":[0.9911528,0.0005744226,0.002617441,0.0000836167,0.000007093044,0.00005753236,0.001056571,0.0001859702,0.004264594],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003541024,"threshold_uncertainty_score":0.01184589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01488639140184535,"score_gpt":0.2434686557515058,"score_spread":0.2285822643496604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}