{"id":"W4386215747","doi":"10.1093/brain/awad286","title":"ALCAM on human oligodendrocytes mediates CD4 T cell adhesion","year":2023,"lang":"en","type":"article","venue":"Brain","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Multiple Sclerosis Society; Multiple Sclerosis Society of Canada; European Genomic Institute for Diabetes","keywords":"ALCAM; Multiple sclerosis; Experimental autoimmune encephalomyelitis; Cell biology; Cell adhesion molecule; Myelin; Oligodendrocyte; Biology; Microglia; Immunology; Inflammation; Neuroscience; Central nervous system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008899398,0.0002178358,0.0001514299,0.0001456103,0.0001599594,0.0002767956,0.0001473885,0.0001739515,0.001319106],"category_scores_gemma":[0.0001507236,0.00007069304,0.0001599665,0.0001171467,0.0001202548,0.0001235422,0.0002022162,0.0002603773,0.0004455876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003008176,"about_ca_system_score_gemma":0.0001984582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001434356,"about_ca_topic_score_gemma":0.001379897,"domain_scores_codex":[0.9998193,0.00002919618,0.000009935766,0.00003309721,0.00005491529,0.00005352743],"domain_scores_gemma":[0.9999372,0.00001352238,0.00001417279,0.000009927663,0.00001458155,0.00001064104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002412994,0.000004809375,0.00008057702,0.00001219002,0.000002061356,0.00002046675,0.00001715854,0.00001268965,0.9991366,0.00004955097,0.00001199092,0.00062782],"study_design_scores_gemma":[0.000004681848,0.00008331834,0.002901311,0.000005499419,0.0000101866,0.0001321038,0.00002869199,0.0007284898,0.9930326,0.00004712427,0.003023217,0.000002677413],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944385,0.001437941,0.00242154,0.0000408591,0.000009638882,0.00001635518,0.0001181209,0.0000260679,0.00149105],"genre_scores_gemma":[0.9948043,0.0009324911,0.001470402,0.00004775604,0.000007134903,0.00002843385,0.0003572175,0.0000101391,0.002342183],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001434356,"threshold_uncertainty_score":0.004412889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02839329537073511,"score_gpt":0.2780894058300973,"score_spread":0.2496961104593622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}