{"id":"W4386222843","doi":"10.3389/fnmol.2023.1221665","title":"Zebrafish as a robust preclinical platform for screening plant-derived drugs with anticonvulsant properties—a review","year":2023,"lang":"en","type":"review","venue":"Frontiers in Molecular Neuroscience","topic":"Zebrafish Biomedical Research Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saint John Regional Hospital","funders":"Uniwersytet Medyczny w Lublinie","keywords":"Zebrafish; Anticonvulsant; Neuroscience; Anticonvulsant drugs; Pharmacology; Medicine; Biology; Epilepsy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006393779,0.001065727,0.00110592,0.003054968,0.0002983564,0.0009143963,0.0007634029,0.0009293341,0.003417584],"category_scores_gemma":[0.0004347691,0.0004387142,0.000651759,0.001489373,0.0004123366,0.001140838,0.0005445744,0.001459666,0.002241546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007569477,"about_ca_system_score_gemma":0.001145793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001869351,"about_ca_topic_score_gemma":0.003962767,"domain_scores_codex":[0.9998137,0.0000277586,0.00002468511,0.00003222248,0.00008225097,0.00001937783],"domain_scores_gemma":[0.9998011,0.00007323579,0.00003197806,0.000008445718,0.00006423028,0.00002099774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001220213,0.000174189,0.0002503984,0.02813868,0.0001043319,0.0004258417,0.00008650774,0.000857608,0.05797537,0.007889216,0.03340285,0.8705729],"study_design_scores_gemma":[0.0000234874,0.0003201805,0.0007249871,0.001655518,0.0001718695,0.0008297568,0.00003267723,0.0002302177,0.01052139,0.001381438,0.9840662,0.00004221265],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007339014,0.9904317,0.002092312,0.0004920384,0.00028021,0.00005305596,0.0002452988,0.0001038187,0.005567667],"genre_scores_gemma":[0.002726044,0.9925537,0.002171517,0.0003031949,0.0001060217,0.00005013866,0.0002573501,0.00001385569,0.001818119],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003417584,"threshold_uncertainty_score":0.01143295,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09357583470410191,"score_gpt":0.3616555012676227,"score_spread":0.2680796665635208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}