{"id":"W4386223379","doi":"10.21203/rs.3.rs-3204554/v1","title":"Native low-density lipoproteins are priming signals of adipose tissue NLRP3 inflammasome/ interleukin-1β pathway in humans","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Inflammasome; Endocrinology; Internal medicine; Apolipoprotein B; Secretion; Adipose tissue; Priming (agriculture); White adipose tissue; Type 2 diabetes; Diabetes mellitus; Chemistry; Medicine; Biology; Inflammation; Cholesterol","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002225247,0.0002309832,0.0002638982,0.0002371496,0.0001833905,0.0006018024,0.00008938922,0.0002546119,0.00142889],"category_scores_gemma":[0.0002948045,0.0001599026,0.0001752614,0.0001988725,0.0002411824,0.0001801839,0.0002022395,0.0003204849,0.0002273263],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009878523,"about_ca_system_score_gemma":0.00009353829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003656555,"about_ca_topic_score_gemma":0.0001973344,"domain_scores_codex":[0.9998919,0.00003580728,0.000010426,0.00003456674,0.00001414073,0.0000132388],"domain_scores_gemma":[0.9999042,0.00001705636,0.00003491524,0.00001278389,0.00001005651,0.00002107944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01509636,0.0007670211,0.7305827,0.0007950575,0.0006060642,0.002392406,0.0007856151,0.0002531648,0.1877407,0.001020135,0.0014872,0.05847366],"study_design_scores_gemma":[0.0002142283,0.001754854,0.9810941,0.00009900286,0.0002841205,0.004034641,0.0003256144,0.0004033183,0.00693238,0.001528379,0.003310414,0.00001889319],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881909,0.008898556,0.001244011,0.0001929256,0.00002947337,0.00001727803,0.0002704297,0.00002560712,0.001130888],"genre_scores_gemma":[0.9977901,0.001206834,0.0004080011,0.0001140804,0.00002530075,0.00001607112,0.0001172761,0.000003816794,0.0003184826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00142889,"threshold_uncertainty_score":0.004780173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04500780011165032,"score_gpt":0.3515811568579751,"score_spread":0.3065733567463248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}