{"id":"W4386223953","doi":"10.3390/jcm12175604","title":"Prevalence and Prognostic Implications of PSA Flares during Radium-223 Treatment among Men with Metastatic Castration Resistant Prostate Cancer","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Medicine","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Regional Municipality of Durham; Juravinski Cancer Centre; Sunnybrook Health Science Centre","funders":"Sanofi Genzyme; Bayer Canada; Astellas Pharma; Endocyte; Bavarian Nordic; Sanofi; Exelixis; Genentech; AstraZeneca; Amgen","keywords":"Medicine; Prostate cancer; Radium-223; Oncology; Cancer; Internal medicine; Radium; Castration; Overall survival; Urology; Gynecology; Hormone; Bone metastasis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003906333,0.0001773123,0.0002353514,0.0006890121,0.0004973595,0.0005708832,0.0004133181,0.0004200363,0.0008111116],"category_scores_gemma":[0.002072335,0.0002267943,0.0002498547,0.0008468453,0.0004092145,0.0002383373,0.0003569053,0.0003630972,0.0001208246],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000751171,"about_ca_system_score_gemma":0.0006844707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.06594685,"about_ca_topic_score_gemma":0.08221707,"domain_scores_codex":[0.9995976,0.00007101049,0.00003347427,0.00008232499,0.0001121414,0.0001034313],"domain_scores_gemma":[0.9986842,0.0001783523,0.0007451926,0.00007451681,0.0001250462,0.0001927567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00004837512,0.000006394203,0.9990282,0.000002681742,0.000009452227,0.00004129067,0.00004098244,0.00001757473,0.0001131022,0.000002915905,0.00002910941,0.0006600503],"study_design_scores_gemma":[0.000001139973,0.00002563504,0.9996548,0.00000121432,0.000006201313,0.0001384818,0.00006075523,0.00004731261,0.00001703879,0.000002549153,0.00004341777,0.000001501797],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994822,0.0001652644,0.00001953964,0.00002203535,0.000001580101,0.000004048667,0.000136819,0.000002028282,0.000166582],"genre_scores_gemma":[0.9997815,0.0000431726,0.00001308932,0.000008299722,0.000003316606,0.00000189131,0.0001068335,6.304213e-7,0.00004124067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06594685,"threshold_uncertainty_score":0.131126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0984310549185754,"score_gpt":0.4515137259980013,"score_spread":0.3530826710794259,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}