{"id":"W4386226539","doi":"10.1016/j.cmet.2023.08.003","title":"A big STEP for treatment of heart failure with preserved ejection fraction","year":2023,"lang":"en","type":"article","venue":"Cell Metabolism","topic":"Cardiovascular Function and Risk Factors","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Novo Nordisk","keywords":"Heart failure with preserved ejection fraction; Heart failure; Medicine; Ejection fraction; Cardiology; Internal medicine; Semaglutide; Inflammation; Obesity; Diabetes mellitus; Type 2 diabetes; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001072131,0.0001150568,0.0003750801,0.0001768088,0.00005549825,0.000008040042,0.00001859262,0.00007863167,0.00004867523],"category_scores_gemma":[0.00001952444,0.00007633431,0.0003265948,0.0003449004,0.00002186865,0.00004172319,0.000005554298,0.00003801032,0.00004231433],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002949123,"about_ca_system_score_gemma":0.00005365366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000149483,"about_ca_topic_score_gemma":0.00003467024,"domain_scores_codex":[0.99928,0.00003461412,0.000142012,0.0001977651,0.0001992679,0.0001463873],"domain_scores_gemma":[0.9994348,0.00003981831,0.00005619932,0.0002746356,0.0001174381,0.00007715783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.006901961,0.002806131,0.3258826,0.001464452,0.004610552,0.00003849391,0.001331253,0.001140809,0.4904577,0.0002200137,0.09236848,0.07277754],"study_design_scores_gemma":[0.003922864,0.0003891915,0.1480078,0.00001445691,0.0006071117,0.000008376536,0.0004526678,0.000199383,0.08773675,0.00000777548,0.7585742,0.00007935706],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929984,0.0006609513,0.003477002,0.0003611475,0.000846258,0.001029247,0.00001785036,0.0001649723,0.0004442053],"genre_scores_gemma":[0.9891518,0.000510607,0.001898097,0.00004230927,0.0007775053,0.0001964691,0.0001398476,0.0000450008,0.007238371],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6662058,"threshold_uncertainty_score":0.3112823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02426817590600457,"score_gpt":0.2559902630805764,"score_spread":0.2317220871745719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}