{"id":"W4386231763","doi":"10.1039/d3ob01297b","title":"C5-Propynyl modified 2′-fluoroarabinonucleic acids form stable duplexes with RNA that are RNase H competent","year":2023,"lang":"en","type":"article","venue":"Organic & Biomolecular Chemistry","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Propynyl; Chemistry; Nucleobase; RNase P; RNA; RNase H; Cleavage (geology); Stereochemistry; Combinatorial chemistry; Biochemistry; DNA; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002228509,0.0004040585,0.0001543487,0.00009163824,0.0001094344,0.0002115029,0.0001712484,0.0003249717,0.0014878],"category_scores_gemma":[0.0002179449,0.0001183078,0.0001559883,0.00005387775,0.0001818098,0.0001763694,0.0001165679,0.0003972307,0.0003790348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002514887,"about_ca_system_score_gemma":0.000175158,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005167821,"about_ca_topic_score_gemma":0.001028689,"domain_scores_codex":[0.9998272,0.00003437384,0.00001118018,0.00005164881,0.00004165721,0.00003386685],"domain_scores_gemma":[0.9998437,0.00003947975,0.0000563568,0.00001609947,0.00001796191,0.00002632764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002820487,0.000005939964,0.00003700332,0.00001132245,0.00000176951,0.00001399195,0.000006277682,0.00003413196,0.9992948,0.00006582723,0.000009740698,0.000490921],"study_design_scores_gemma":[0.000002882608,0.0001082857,0.0004116726,0.000001434922,0.000002596568,0.00006062852,0.000006042634,0.0001989006,0.9982247,0.00001475841,0.000966115,0.000002062113],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883377,0.0004547432,0.00846979,0.00003825476,0.00003361078,0.00005628768,0.0001626801,0.00008646715,0.002360533],"genre_scores_gemma":[0.9907453,0.0001329752,0.00557995,0.00003667257,0.000004756982,0.00004368728,0.000306008,0.00002563429,0.00312512],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0014878,"threshold_uncertainty_score":0.004977167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009916763040457417,"score_gpt":0.2088983955016109,"score_spread":0.1989816324611535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}