{"id":"W4386243741","doi":"10.1016/s1470-2045(23)00268-1","title":"Neoadjuvant palbociclib plus either giredestrant or anastrozole in oestrogen receptor-positive, HER2-negative, early breast cancer (coopERA Breast Cancer): an open-label, randomised, controlled, phase 2 study","year":2023,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"Genentech; F. Hoffmann-La Roche; Roche; Amgen","keywords":"Anastrozole; Medicine; Palbociclib; Breast cancer; Internal medicine; Oncology; Clinical endpoint; Cancer; Gynecology; Regimen; Phases of clinical research; Tamoxifen; Clinical trial; Metastatic breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003045715,0.001929973,0.003821496,0.0008487368,0.0004816986,0.001110224,0.001374373,0.001764547,0.006852421],"category_scores_gemma":[0.001796825,0.001268863,0.001465781,0.0006992429,0.001685784,0.001384989,0.0006095463,0.002878273,0.001427267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001106741,"about_ca_system_score_gemma":0.002390748,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001341507,"about_ca_topic_score_gemma":0.003243719,"domain_scores_codex":[0.9988773,0.0006220542,0.00006695669,0.0001812186,0.00010127,0.0001511889],"domain_scores_gemma":[0.9985943,0.0003585909,0.0003082785,0.0001376207,0.00007568325,0.0005254065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9632006,0.02005138,0.0005982051,0.0004843974,0.0002982241,0.00003141587,0.00004696834,0.0002619561,0.004694215,0.00006039465,0.0003941709,0.009878214],"study_design_scores_gemma":[0.8103378,0.187493,0.001036508,0.00001747301,0.0001445719,0.0000239916,0.00001416841,0.0001268434,0.0003365591,0.00004461499,0.0004141571,0.00001032212],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880035,0.002278055,0.0003623171,0.0003875517,0.0003294082,0.006049106,0.00100405,0.00009346755,0.001492467],"genre_scores_gemma":[0.9762146,0.002751816,0.002378757,0.0009311888,0.0006755378,0.01175677,0.001417255,0.00003462491,0.003839551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006852421,"threshold_uncertainty_score":0.02292365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07426775205635529,"score_gpt":0.4172809460025809,"score_spread":0.3430131939462256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}