{"id":"W4386243741","doi":"10.1016/s1470-2045(23)00268-1","title":"Neoadjuvant palbociclib plus either giredestrant or anastrozole in oestrogen receptor-positive, HER2-negative, early breast cancer (coopERA Breast Cancer): an open-label, randomised, controlled, phase 2 study","year":2023,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"Genentech; F. Hoffmann-La Roche; Roche; Amgen","keywords":"Anastrozole; Medicine; Palbociclib; Breast cancer; Internal medicine; Oncology; Clinical endpoint; Cancer; Gynecology; Regimen; Phases of clinical research; Tamoxifen; Clinical trial; Metastatic breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001687196,0.0007268942,0.003023547,0.0002514717,0.0003655417,0.000121585,0.001200813,0.0002495016,0.001895515],"category_scores_gemma":[0.00008326144,0.0004521298,0.0001230449,0.001314794,0.0005873942,0.0005351139,0.0003286059,0.0009598174,0.0001063191],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001299349,"about_ca_system_score_gemma":0.00175352,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01393504,"about_ca_topic_score_gemma":0.01143871,"domain_scores_codex":[0.9943081,0.00154782,0.001049108,0.001077612,0.000554654,0.001462781],"domain_scores_gemma":[0.9969176,0.0007291394,0.0005308205,0.0010117,0.0003930814,0.0004176573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.753777,0.00586485,0.03328549,0.00007570603,0.00213706,0.001243089,0.01011324,0.001097671,0.01330788,0.00007240919,0.001534741,0.1774908],"study_design_scores_gemma":[0.7934967,0.007099376,0.1858438,0.0004899472,0.0006193965,0.0006832085,0.00610908,0.001469353,0.0004009867,0.00008582977,0.002944551,0.0007577357],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9683664,0.0004632045,0.00004193318,0.01949051,0.000606716,0.00851032,0.001736571,0.0003002163,0.0004841609],"genre_scores_gemma":[0.9865569,0.00099936,0.0004619732,0.00276375,0.001620022,0.005803074,0.00008038591,0.0001902693,0.001524243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1767331,"threshold_uncertainty_score":0.9997931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07426775205635529,"score_gpt":0.4172809460025809,"score_spread":0.3430131939462256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}