{"id":"W4386244235","doi":"10.1016/j.atherosclerosis.2023.06.805","title":"ARO-ANG3, an investigational RNAI therapeutic, decreases serum LDL-cholesterol, apolipoprotein B, and angiopoietin-like protein 3 in patients with homozygous familial hypercholesterolaemia","year":2023,"lang":"en","type":"article","venue":"Atherosclerosis","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Robarts Clinical Trials; Université de Montréal; Université du Québec à Chicoutimi; Université Laval","funders":"","keywords":"Apolipoprotein B; Ldl cholesterol; Cholesterol; PCSK9; Medicine; RNA interference; Angiopoietin 2; Pharmacology; Internal medicine; LDL receptor; Chemistry; Lipoprotein; Biochemistry; Gene; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006564518,0.0004388943,0.0006284422,0.0002896949,0.0002189703,0.0001054198,0.0001892828,0.0002538736,0.00002520434],"category_scores_gemma":[0.00005524839,0.0003567627,0.00015461,0.000727708,0.0002641092,0.0003777509,0.0001045185,0.0004095846,0.00004780194],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001451579,"about_ca_system_score_gemma":0.0002040966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001561908,"about_ca_topic_score_gemma":0.0004097716,"domain_scores_codex":[0.9967645,0.0002601645,0.0004729882,0.0008000856,0.0009782437,0.0007240655],"domain_scores_gemma":[0.9982892,0.00003337237,0.0001344851,0.0008463582,0.0001593341,0.0005372424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000612941,0.0006767921,0.9476681,0.0002319803,0.0002211236,0.00002244489,0.0009974958,0.00001499924,0.007864604,0.00008685742,0.00006992152,0.04153272],"study_design_scores_gemma":[0.00651508,0.00151158,0.9886081,0.0004753753,0.0001041078,0.00001920798,0.000210551,0.00007783411,0.001528086,0.0001462118,0.0004236812,0.0003801699],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961961,0.0001222568,0.00002828549,0.0008018859,0.00007793117,0.002408243,0.0000633665,0.0002518392,0.00005010219],"genre_scores_gemma":[0.9961817,0.00006486135,0.000842994,0.001706882,0.0002108753,0.0005133406,0.0001752144,0.0001277191,0.0001764571],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04115255,"threshold_uncertainty_score":0.9998884,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01804662441231256,"score_gpt":0.2352761935212519,"score_spread":0.2172295691089394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}