{"id":"W4386244235","doi":"10.1016/j.atherosclerosis.2023.06.805","title":"ARO-ANG3, an investigational RNAI therapeutic, decreases serum LDL-cholesterol, apolipoprotein B, and angiopoietin-like protein 3 in patients with homozygous familial hypercholesterolaemia","year":2023,"lang":"en","type":"article","venue":"Atherosclerosis","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Robarts Clinical Trials; Université de Montréal; Université du Québec à Chicoutimi; Université Laval","funders":"","keywords":"Apolipoprotein B; Ldl cholesterol; Cholesterol; PCSK9; Medicine; RNA interference; Angiopoietin 2; Pharmacology; Internal medicine; LDL receptor; Chemistry; Lipoprotein; Biochemistry; Gene; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001827039,0.0002952199,0.0004395248,0.0001830813,0.0002398016,0.0002134286,0.0001390842,0.0003599843,0.001032506],"category_scores_gemma":[0.0001671573,0.0001271479,0.0002906842,0.0001369678,0.0001786949,0.00009902602,0.00009822399,0.0004723539,0.0001662737],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001744846,"about_ca_system_score_gemma":0.0001860641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006850284,"about_ca_topic_score_gemma":0.001665519,"domain_scores_codex":[0.9999142,0.00002341499,0.000009817205,0.00001630821,0.00001931649,0.00001705199],"domain_scores_gemma":[0.9999397,0.00001202486,0.00001651793,0.000004242419,0.000005828756,0.0000216157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.03376653,0.002760638,0.04113804,0.0001759001,0.000578568,0.002069015,0.0002004659,0.0002668907,0.8447739,0.0002297073,0.002171469,0.07186892],"study_design_scores_gemma":[0.01140279,0.0467928,0.6839005,0.00007344586,0.002770524,0.01356594,0.0007531572,0.007238813,0.2190769,0.0007977889,0.01351765,0.000109777],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977527,0.0007456164,0.000419347,0.0001581782,0.00003173856,0.00001192789,0.00007474468,0.00005518853,0.0007505157],"genre_scores_gemma":[0.9983305,0.0002950942,0.0004858891,0.0001178209,0.0000195678,0.00001458923,0.0001112581,0.000005864917,0.0006194038],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001032506,"threshold_uncertainty_score":0.003454089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01804662441231256,"score_gpt":0.2352761935212519,"score_spread":0.2172295691089394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}