{"id":"W4386249643","doi":"10.1073/pnas.2302720120","title":"Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by <i>HLA-DRB1*04</i> subtypes","year":2023,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Brain Institute; Montreal Neurological Institute and Hospital; University of Toronto; University Health Network; McGill University; Occupational Cancer Research Centre","funders":"National Institute on Aging; RIKEN; Universitätsklinikum Köln; Alzheimer's Association; Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta; Universität zu Köln; Göteborgs Universitet; University of Oxford; Sahlgrenska Universitetssjukhuset; UK Dementia Research Institute; Universitetet i Oslo; University of Toronto; EU Joint Programme – Neurodegenerative Disease Research; Institut National de la Santé et de la Recherche Médicale; National Institute of Neurological Disorders and Stroke; Sahlgrenska Akademin; Vetenskapsrådet; Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease; Japan Agency for Medical Research and Development; Deutsches Zentrum für Neurodegenerative Erkrankungen; Universidade de Aveiro; Cardiff University; Västra Götalandsregionen; University of Bristol; Medical Research Council; Michael J. Fox Foundation for Parkinson's Research","keywords":"Human leukocyte antigen; Parkinson's disease; Locus (genetics); Immune system; Disease; Biology; Neuroscience; Immunology; Genetics; Medicine; Gene; Antigen; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004808183,0.0002132382,0.000242942,0.0007894818,0.000393394,0.0002893903,0.0002329825,0.0002484427,0.001374675],"category_scores_gemma":[0.001204301,0.0001593978,0.0003128484,0.0005196032,0.0002879183,0.0001886859,0.0005477546,0.0003795334,0.0001732697],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001525583,"about_ca_system_score_gemma":0.00009120714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001356368,"about_ca_topic_score_gemma":0.001575171,"domain_scores_codex":[0.9994905,0.0001768006,0.00004462607,0.0001709984,0.00005165639,0.0000653457],"domain_scores_gemma":[0.9991353,0.0001564584,0.0003697763,0.0001567957,0.0000585834,0.000123085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008833373,0.000046969,0.9482899,0.00001763846,0.0003670923,0.000305167,0.0003861417,0.0001841011,0.04230792,0.0001898772,0.00009875475,0.006922982],"study_design_scores_gemma":[0.00001297128,0.000218034,0.9965634,0.000003212196,0.00006262992,0.0009086397,0.000136585,0.0003390904,0.001255544,0.0001756781,0.000319407,0.000004788496],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995078,0.0000606088,0.000243895,0.00001058337,0.000001104233,0.000002055177,0.00004316938,0.000002174197,0.0001286594],"genre_scores_gemma":[0.9996502,0.00001647449,0.0001782247,0.000006069591,0.000001644205,0.00000196267,0.00006683803,0.000001995328,0.00007661177],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001374675,"threshold_uncertainty_score":0.004598677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05959565918225703,"score_gpt":0.3004695750487366,"score_spread":0.2408739158664795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}