{"id":"W4386252008","doi":"10.1017/cjn.2023.281","title":"Disease Progression and Sphingolipids and Neurofilament Light Chain in Early Idiopathic Parkinson’s Disease","year":2023,"lang":"en","type":"article","venue":"Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Toronto Western Hospital","funders":"Avid Radiopharmaceuticals; Sanofi Genzyme; Allergan; Genentech; H. Lundbeck A/S; Servier; Voyager Therapeutics; Neurocrine Biosciences; Denali Therapeutics; Biogen; Celgene; Verily Life Sciences; Teva Pharmaceutical Industries; Sanofi; GlaxoSmithKline; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Sphingolipid; Biomarker; Internal medicine; Medicine; Disease; Oncology; Cohort; Montreal Cognitive Assessment; Cerebrospinal fluid; Parkinson's disease; Dementia; Pathology; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001181358,0.0003755678,0.0003742517,0.0007150327,0.0003050478,0.0006463773,0.0003291568,0.0004386324,0.000773606],"category_scores_gemma":[0.002760039,0.0002793933,0.0004671283,0.0005702796,0.0002657385,0.0004386465,0.0004092782,0.0007213916,0.0001451725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003281007,"about_ca_system_score_gemma":0.0004072768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007254298,"about_ca_topic_score_gemma":0.007703374,"domain_scores_codex":[0.9997132,0.0001064883,0.00002618014,0.00006901682,0.00004886344,0.00003613067],"domain_scores_gemma":[0.998659,0.0003805732,0.0005511501,0.0001252423,0.00009696952,0.0001869121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008011649,0.00004821525,0.996576,0.000008529479,0.00008953717,0.00007524637,0.00005652998,0.0001825089,0.0004191222,0.00002242016,0.00003129901,0.001689523],"study_design_scores_gemma":[0.00002005457,0.0002387897,0.9978102,0.000006247509,0.00006862316,0.0002597707,0.00005228267,0.001110748,0.0002050938,0.00008510419,0.0001389057,0.000004078975],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993197,0.0002851908,0.0001047116,0.00001800029,0.000002169583,0.000003507076,0.0001419126,0.000003738893,0.0001211824],"genre_scores_gemma":[0.9993846,0.00008105404,0.0001110472,0.000007826992,0.000003543166,0.000003191756,0.0002551326,0.000001362941,0.000152102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007254298,"threshold_uncertainty_score":0.01442415,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02693687436282359,"score_gpt":0.2782917431259097,"score_spread":0.251354868763086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}