{"id":"W4386256813","doi":"10.3233/jad-230548","title":"Pathway-Specific Polygenic Risk Scores Correlate with Clinical Status and Alzheimer’s Disease-Related Biomarkers","year":2023,"lang":"en","type":"article","venue":"Journal of Alzheimer s Disease","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Novartis Pharmaceuticals Corporation; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; BioClinica; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; National Institute on Aging; Alzheimer's Association","keywords":"Disease; Neurodegeneration; Medicine; Alzheimer's disease; Bioinformatics; Apolipoprotein E; Neuroscience; Biology; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001081123,0.0006356109,0.0003351877,0.001138972,0.0003446406,0.0006065299,0.000297529,0.0004118797,0.003109418],"category_scores_gemma":[0.004192661,0.000199835,0.0008853193,0.001220631,0.0003578107,0.0003700746,0.0007949562,0.000525204,0.000223544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002873577,"about_ca_system_score_gemma":0.0004991828,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004087287,"about_ca_topic_score_gemma":0.004652015,"domain_scores_codex":[0.9992483,0.0002413977,0.00006865656,0.0002632116,0.000079142,0.00009933809],"domain_scores_gemma":[0.9962776,0.001242612,0.001475022,0.0004210644,0.0002777959,0.0003058542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000193766,0.00002139357,0.994175,0.00001359305,0.0003230676,0.00007537943,0.00004385943,0.0005148135,0.001042809,0.0001102084,0.0000947941,0.003391273],"study_design_scores_gemma":[0.000007593011,0.00006668853,0.9962031,0.000006603021,0.0001238086,0.0002965675,0.00004040345,0.00219103,0.0002224563,0.0007141856,0.0001213852,0.000006169466],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964374,0.0001232145,0.002295969,0.00006206367,0.000003091825,0.00001633808,0.000652127,0.00002302037,0.0003867901],"genre_scores_gemma":[0.9986166,0.00003101847,0.0008107127,0.000007096675,0.00000263569,0.000008120982,0.0004246464,0.000004910943,0.00009427105],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004087287,"threshold_uncertainty_score":0.01040208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0497895429782124,"score_gpt":0.3366844014574722,"score_spread":0.2868948584792598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}