{"id":"W4386269906","doi":"10.1016/j.jpeds.2023.113705","title":"Timing for First-in-Minor Clinical Trials of New Cancer Drugs","year":2023,"lang":"en","type":"article","venue":"The Journal of Pediatrics","topic":"Pharmaceutical studies and practices","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Narodowe Centrum Nauki; Genome Canada","keywords":"Medicine; Clinical trial; Drug; Drug approval; Food and drug administration; Cancer drugs; Cancer; Clinical pharmacology; Pharmacology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.01257951,0.00006637043,0.0005675598,0.00008900629,0.00004679362,0.000005084241,0.0001217526,0.00005390981,0.00007504602],"category_scores_gemma":[0.009217698,0.00003599497,0.0002472661,0.0003453642,0.00002956858,0.00005656061,0.00004072902,0.0003144504,0.000005604124],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002896953,"about_ca_system_score_gemma":0.0002261583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005726661,"about_ca_topic_score_gemma":0.0000178728,"domain_scores_codex":[0.9981833,0.0001993565,0.001142627,0.00005363494,0.0002565898,0.0001645444],"domain_scores_gemma":[0.9872261,0.01149325,0.0009303568,0.00007831403,0.0001452455,0.0001267718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.009844805,0.000359374,0.1579564,0.001125536,0.0003208508,0.00004990415,0.004250973,0.0007060181,0.0001773073,0.00007761995,0.5886295,0.2365017],"study_design_scores_gemma":[0.03278444,0.003514756,0.1426214,0.0004659337,0.0148134,0.00008489133,0.00562154,0.00286084,0.0009194146,0.003747103,0.7921214,0.0004448948],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9373105,0.01405295,0.0002888369,0.04598863,0.001632202,0.0004147792,0.00001891559,0.000008355333,0.0002848511],"genre_scores_gemma":[0.823314,0.1635935,0.0007197584,0.001138797,0.01010928,0.000004283732,0.000001179773,0.00002247687,0.001096773],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2360568,"threshold_uncertainty_score":0.9991281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4966076840140673,"score_gpt":0.5758681365385451,"score_spread":0.07926045252447778,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}