{"id":"W4386270458","doi":"10.1016/s2152-2650(23)00489-5","title":"POSTER: AML-475 Activity, Tolerability, and Resistance Profile of the Menin Inhibitor Ziftomenib in Adults With Relapsed/Refractory NPM1-Mutated AML","year":2023,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hotel Dieu Hospital","funders":"","keywords":"Tolerability; Refractory (planetary science); NPM1; Medicine; Internal medicine; Cancer research; Oncology; Chemistry; Biology; Adverse effect; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003096224,0.0002794631,0.0004504431,0.0001109446,0.000166031,0.0003481614,0.0001436238,0.0002476528,0.005149261],"category_scores_gemma":[0.0004508065,0.00008386462,0.0003401671,0.00009419861,0.0001106433,0.0002128977,0.0001106802,0.0007926131,0.0007297356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003837014,"about_ca_system_score_gemma":0.0002089652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006649636,"about_ca_topic_score_gemma":0.001308914,"domain_scores_codex":[0.9999156,0.00002114463,0.000007785176,0.00001413189,0.00001817891,0.00002318575],"domain_scores_gemma":[0.9998758,0.00002845061,0.00002730782,0.00000558929,0.00001311556,0.00004974805],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.2193882,0.004403565,0.04807085,0.000847065,0.001448727,0.001363387,0.0003889148,0.002905039,0.08703627,0.0006779907,0.05453086,0.578939],"study_design_scores_gemma":[0.04424816,0.2130761,0.5669533,0.000328099,0.003167631,0.007232356,0.0004004512,0.006817555,0.06526764,0.0009200615,0.09145389,0.0001347975],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9752595,0.01088266,0.0004742835,0.002512574,0.0003333429,0.0001959906,0.002449702,0.0001240107,0.007768049],"genre_scores_gemma":[0.9901535,0.002483094,0.000297885,0.0009673478,0.0002496201,0.00005096853,0.001240392,0.0000164986,0.004540705],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005149261,"threshold_uncertainty_score":0.01722604,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01889096528625123,"score_gpt":0.2969207097104689,"score_spread":0.2780297444242176,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}