{"id":"W4386270690","doi":"10.1016/s2152-2650(23)00568-2","title":"POSTER: CML-319 Molecular Response of ≤10% BCR::ABL1IS Is Predictive of Positive Outcomes in Patients With Treatment-Resistant Chronic-Phase Chronic Myeloid Leukemia (CP-CML) Treated With Ponatinib From the Phase 2 OPTIC Trial","year":2023,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Ponatinib; Myeloid leukemia; Medicine; Internal medicine; Oncology; Cancer research; Nilotinib; Imatinib","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001071176,0.0003921702,0.000502874,0.0001817053,0.00035583,0.0007556363,0.0003024755,0.0006888394,0.02588637],"category_scores_gemma":[0.00166352,0.0001313216,0.0006272792,0.0002002138,0.0001802913,0.0004860923,0.0003952173,0.001091382,0.003941607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000459184,"about_ca_system_score_gemma":0.0006215658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004021753,"about_ca_topic_score_gemma":0.001327539,"domain_scores_codex":[0.9997564,0.00009535256,0.00001828863,0.00004060538,0.00003976168,0.00004963128],"domain_scores_gemma":[0.9991745,0.0001563257,0.0001575569,0.00003897382,0.00008506936,0.0003875291],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2540514,0.002576906,0.1288108,0.001363927,0.00144764,0.000335911,0.0001702523,0.00138615,0.009817338,0.0009305489,0.3579393,0.24117],"study_design_scores_gemma":[0.09435278,0.0398998,0.6527825,0.0006626055,0.003000008,0.001268344,0.0002120045,0.002521075,0.006813488,0.003262476,0.195095,0.0001299249],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8226051,0.01005202,0.0008196913,0.03792251,0.004258191,0.001789304,0.05380156,0.0004092766,0.06834242],"genre_scores_gemma":[0.928178,0.003743017,0.001203881,0.01027679,0.004115974,0.0007862058,0.02415232,0.00009439154,0.02744942],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02588637,"threshold_uncertainty_score":0.08659852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02001038877133748,"score_gpt":0.3236364272275156,"score_spread":0.3036260384561781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}