{"id":"W4386270699","doi":"10.1016/s2152-2650(23)01449-0","title":"MM-388 Idecabtagene Vicleucel (ide-cel) Versus Standard Regimens in Patients With Triple-Class–Exposed (TCE) Relapsed and Refractory Multiple Myeloma (RRMM): A KarMMa-3 Analysis in High-Risk Subgroups","year":2023,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Celgene; Bristol-Myers Squibb","keywords":"Refractory (planetary science); Medicine; Internal medicine; Multiple myeloma; Oncology; Lenalidomide; Materials science; Metallurgy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000794574,0.0003747061,0.001118333,0.0002788465,0.0001505091,0.0006295927,0.000388035,0.0004224904,0.001625205],"category_scores_gemma":[0.0008018822,0.0001701178,0.001090963,0.000257706,0.0003134006,0.0006336835,0.0002869031,0.001079269,0.000201359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005839315,"about_ca_system_score_gemma":0.0004299663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006173236,"about_ca_topic_score_gemma":0.001660266,"domain_scores_codex":[0.9995059,0.000191881,0.00002618325,0.00009892545,0.00004719651,0.0001299723],"domain_scores_gemma":[0.9995938,0.0001368601,0.00007813791,0.00002964604,0.00001458308,0.0001470085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.7972431,0.003333698,0.0838526,0.0002254831,0.002798658,0.0001690173,0.000154257,0.00140654,0.008786286,0.0002601338,0.001103292,0.1006669],"study_design_scores_gemma":[0.1001236,0.3198662,0.5548203,0.0001436408,0.005084938,0.0008035354,0.0005425753,0.00702041,0.004167858,0.001705273,0.005628452,0.00009331975],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981441,0.00105894,0.00006131772,0.00008236027,0.00002476897,0.00002645335,0.0001268127,0.000008241547,0.0004669689],"genre_scores_gemma":[0.9991326,0.0002071295,0.00008676722,0.00009111495,0.00002853919,0.0000229994,0.0001838925,0.000002372096,0.0002446935],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001625205,"threshold_uncertainty_score":0.005436897,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02732845351723355,"score_gpt":0.3056269084531221,"score_spread":0.2782984549358886,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}