{"id":"W4386270996","doi":"10.1016/s2152-2650(23)00655-9","title":"POSTER: MPN-346 INDEPENDENCE: Enrolling Phase III Trial to Study the Efficacy and Safety of Luspatercept versus Placebo in Patients With Myelofibrosis on JAK2 Inhibitor (JAK2i) Therapy Requiring Red Blood Cell Transfusions (RBCTs)","year":2023,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Myelofibrosis; Placebo; Medicine; Internal medicine; Phases of clinical research; Clinical trial; Bone marrow; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001866106,0.001401979,0.001924069,0.0002735677,0.0005558152,0.001141844,0.0006582441,0.00213452,0.01341696],"category_scores_gemma":[0.001331238,0.0005492842,0.001886922,0.0002341863,0.0007020931,0.001047435,0.0003562555,0.005325136,0.002265082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006816445,"about_ca_system_score_gemma":0.00122946,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006659149,"about_ca_topic_score_gemma":0.001683994,"domain_scores_codex":[0.999598,0.0001702202,0.00002380924,0.00007670507,0.00003833408,0.00009289416],"domain_scores_gemma":[0.9991911,0.0001681713,0.0001426163,0.00004852357,0.00004448351,0.0004051807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9116465,0.01108262,0.001404695,0.0005031426,0.001168946,0.00008256028,0.00007176958,0.0007052256,0.01006606,0.0002101239,0.01079319,0.05226527],"study_design_scores_gemma":[0.8998053,0.09073871,0.004512318,0.00003220899,0.0004575086,0.00004083427,0.00001299989,0.0003711992,0.000900756,0.0002005277,0.002907496,0.00002014645],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9534407,0.007092335,0.00157515,0.009160281,0.002356528,0.008026057,0.008737119,0.0004813104,0.009130506],"genre_scores_gemma":[0.9521158,0.003762785,0.003749187,0.00855168,0.001987741,0.005889713,0.006315093,0.0001188333,0.01750911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01341696,"threshold_uncertainty_score":0.04488415,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04201963712057837,"score_gpt":0.3397200616766584,"score_spread":0.29770042455608,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}