{"id":"W4386271023","doi":"10.1016/s2152-2650(23)00732-2","title":"POSTER: ABCL-187 Phase 2 Response-Adapted Study of Ibrutinib With Temozolomide, Etoposide, Liposomal Doxorubicin, Dexamethasone, Rituximab (TEDDI-R) for Secondary CNS Lymphoma","year":2023,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Spinal Cord Injury BC; University of British Columbia","funders":"","keywords":"Ibrutinib; Temozolomide; Rituximab; Medicine; Etoposide; Dexamethasone; Lymphoma; Doxorubicin; Pharmacology; Oncology; Internal medicine; Chemotherapy; Leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001046355,0.001365555,0.001714918,0.0002998312,0.0004158851,0.0007512251,0.0007878728,0.001059056,0.01209228],"category_scores_gemma":[0.0005153278,0.0004223595,0.001258842,0.0001913791,0.0005497786,0.0004498574,0.0003525946,0.003289895,0.002428698],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009412249,"about_ca_system_score_gemma":0.001193609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001946966,"about_ca_topic_score_gemma":0.004983535,"domain_scores_codex":[0.999702,0.0001012131,0.00001498298,0.00004405302,0.00003161666,0.0001060173],"domain_scores_gemma":[0.9996829,0.00004579483,0.00003199261,0.00001759772,0.00002245247,0.0001993544],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5948761,0.03898988,0.004111335,0.001509507,0.002367111,0.0008405757,0.0003147944,0.004191691,0.04576499,0.0009034825,0.06838053,0.23775],"study_design_scores_gemma":[0.6248606,0.3063334,0.0207658,0.00009161539,0.0009797831,0.0008317279,0.00008374102,0.001915356,0.009426595,0.0004364763,0.03421477,0.00006022621],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9576623,0.008200601,0.001609938,0.003950191,0.001561853,0.004389976,0.006699566,0.0005424933,0.01538298],"genre_scores_gemma":[0.9482385,0.004707139,0.002764985,0.004680946,0.0008004951,0.002279088,0.008913883,0.0001581349,0.02745675],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01209228,"threshold_uncertainty_score":0.04045272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04750053828667632,"score_gpt":0.3651694180102589,"score_spread":0.3176688797235825,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}