{"id":"W4386271158","doi":"10.1016/s2152-2650(23)01066-2","title":"AML-469 Ivosidenib + Azacitidine vs Placebo + Azacitidine in Patients With Newly-Diagnosed Acute Myeloid Leukemia: Updated Long-term Efficacy and Safety Results From the AGILE Study","year":2023,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Azacitidine; Myeloid leukemia; Medicine; Placebo; Term (time); Oncology; Internal medicine; Alternative medicine; Biology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001348336,0.0006822639,0.002337452,0.0003210852,0.0001847853,0.0009974308,0.0005058863,0.0005173923,0.001970526],"category_scores_gemma":[0.001497681,0.0003031485,0.001643342,0.000504541,0.0004473747,0.0007138049,0.0003450798,0.002170811,0.0003386004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005070874,"about_ca_system_score_gemma":0.0005695869,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007876509,"about_ca_topic_score_gemma":0.002686756,"domain_scores_codex":[0.9994407,0.0002842263,0.00004827515,0.00008218837,0.00007450188,0.00007015825],"domain_scores_gemma":[0.9989626,0.0003418257,0.0003584838,0.00007275783,0.00005465579,0.0002097185],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7787762,0.003219533,0.01784723,0.001482909,0.007674708,0.00009978057,0.0001192908,0.001352646,0.007313789,0.0002944396,0.003255971,0.1785634],"study_design_scores_gemma":[0.7430005,0.1277774,0.1038353,0.0003622972,0.01099894,0.0004518866,0.000204619,0.00151423,0.002584645,0.0007924506,0.008384891,0.00009287576],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9638172,0.02946554,0.0004561509,0.0007069394,0.0002953268,0.0003670091,0.002059062,0.00009073533,0.00274209],"genre_scores_gemma":[0.9820817,0.01152503,0.0009629233,0.001035181,0.0003466521,0.0003149525,0.002202436,0.00002135758,0.001509732],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002337452,"threshold_uncertainty_score":0.007130742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02545586208693558,"score_gpt":0.316729295405215,"score_spread":0.2912734333182794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}