{"id":"W4386271177","doi":"10.1016/s2152-2650(23)01250-8","title":"MPN-524 Reductions in Indolent Systemic Mastocytosis Biomarker Burden With Avapritinib in the Registrational, Double-Blind, Placebo-Controlled PIONEER Trial","year":2023,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; University of Calgary","funders":"","keywords":"Double blind; Biomarker; Placebo; Systemic mastocytosis; Medicine; Internal medicine; Pathology; Chemistry; Disease; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001485867,0.001418879,0.003115235,0.0002786413,0.0003825482,0.0009138597,0.0008142413,0.001395622,0.004727622],"category_scores_gemma":[0.00105935,0.0004594752,0.001806868,0.0002577859,0.0009070595,0.001054259,0.0002707168,0.003074174,0.0009453447],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006319333,"about_ca_system_score_gemma":0.0006501188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007113175,"about_ca_topic_score_gemma":0.001873897,"domain_scores_codex":[0.9995679,0.0001828026,0.00002140435,0.00008800953,0.00004379437,0.00009595804],"domain_scores_gemma":[0.9996113,0.00009227663,0.00009008627,0.00004404436,0.00003697591,0.0001253754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9395516,0.003047727,0.0006760759,0.001414739,0.001847405,0.00005866501,0.00005150252,0.0005639314,0.008100787,0.0002531928,0.002778384,0.04165606],"study_design_scores_gemma":[0.9213719,0.06943679,0.004850925,0.00005862027,0.0008511821,0.0000915038,0.00003103344,0.0005201834,0.001061589,0.0002636326,0.001432491,0.00003011297],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9760013,0.01464035,0.000901759,0.001081008,0.0007358164,0.001408954,0.00135433,0.0004755931,0.003400878],"genre_scores_gemma":[0.9886233,0.003772395,0.0009336643,0.000809025,0.000438593,0.0009623966,0.00107236,0.0000384515,0.003349804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004727622,"threshold_uncertainty_score":0.0158155,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06755286897072173,"score_gpt":0.3249716465879161,"score_spread":0.2574187776171943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}