{"id":"W4386272196","doi":"10.1016/j.jconrel.2023.08.041","title":"An insight on ophthalmic drug delivery systems: Focus on polymeric biomaterials-based carriers","year":2023,"lang":"en","type":"review","venue":"Journal of Controlled Release","topic":"Ocular Surface and Contact Lens","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":false,"ca_institutions":"National Institute for Nanotechnology; University of Waterloo","funders":"","keywords":"Nanocarriers; Drug delivery; Clearance; Nanotechnology; Cornea; Drug; Nanomedicine; Targeted drug delivery; Drug carrier; Liposome; Chemistry; Biomedical engineering; Materials science; Pharmacology; Nanoparticle; Medicine; Ophthalmology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001045488,0.00083269,0.006457965,0.001464524,0.0001278365,0.0001403498,0.0004211039,0.0005033669,0.00007556476],"category_scores_gemma":[0.0003672488,0.0005220082,0.002485435,0.0005264803,0.0000579084,0.0001199137,0.00001937553,0.0007299856,0.0002717646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005246806,"about_ca_system_score_gemma":0.002623723,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001212048,"about_ca_topic_score_gemma":0.000003623992,"domain_scores_codex":[0.9943346,0.001255402,0.002297606,0.0004468559,0.001101102,0.0005644247],"domain_scores_gemma":[0.9945891,0.0007354721,0.002593847,0.0008542475,0.0003663659,0.0008609405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.06798265,0.004181098,0.00006298431,0.05692137,0.02321955,0.08078314,0.0003111003,0.0005312783,0.002313812,0.0002473962,0.003056813,0.7603888],"study_design_scores_gemma":[0.07078549,0.0143472,0.00002305898,0.1825772,0.02993653,0.001394392,0.0003586758,0.0006225783,0.0004679599,0.00002011732,0.6974632,0.002003652],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02472195,0.9699934,0.000006991815,0.0001974355,0.002539867,0.002029282,0.00008992341,0.00007770787,0.0003434406],"genre_scores_gemma":[0.06595825,0.9314274,0.00001055586,0.0002636398,0.001449987,0.00007094791,0.00004495317,0.0002234737,0.0005508568],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7583852,"threshold_uncertainty_score":0.9997231,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02751221944479514,"score_gpt":0.3160085340400691,"score_spread":0.288496314595274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}