{"id":"W4386277230","doi":"10.1016/s2152-2650(23)00617-1","title":"POSTER: MDS-641 Randomized Phase 1-2 Study to Assess Safety and Efficacy of Low-Dose (LD) Oral Decitabine/Cedazuridine (ASTX727) in Lower-Risk Myelodysplastic Syndromes (LR-MDS) Patients: Interim Safety Analysis","year":2023,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta Hospital; London Health Sciences Centre","funders":"","keywords":"Decitabine; Interim analysis; Medicine; Myelodysplastic syndromes; Interim; Safety profile; Randomized controlled trial; Oncology; Internal medicine; Adverse effect; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001873054,0.002089261,0.002669022,0.0004793596,0.0005290091,0.001046986,0.0007643477,0.001475371,0.01342385],"category_scores_gemma":[0.001494416,0.0008128401,0.002138764,0.0003490738,0.001033408,0.0008070283,0.0004258271,0.003755719,0.002147055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001106565,"about_ca_system_score_gemma":0.001769491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008726893,"about_ca_topic_score_gemma":0.002500725,"domain_scores_codex":[0.9994606,0.0003073835,0.00002789976,0.00008646087,0.0000375249,0.00008006297],"domain_scores_gemma":[0.9991893,0.0001747148,0.0002143286,0.00007793619,0.00005133035,0.0002923813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9528493,0.006551282,0.001283805,0.0005287855,0.001266531,0.00006130994,0.00005344846,0.0009713316,0.006888781,0.000172466,0.003563945,0.02580901],"study_design_scores_gemma":[0.9246036,0.06860369,0.0028338,0.0000350885,0.0005664871,0.00004793121,0.00001370246,0.0003541411,0.0008324487,0.0002413838,0.001848365,0.0000192231],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9715471,0.004536632,0.001624611,0.001848819,0.0006269451,0.006510989,0.007275621,0.0004002317,0.005629106],"genre_scores_gemma":[0.9630589,0.002731419,0.00398023,0.002737137,0.0005322064,0.006382748,0.006931467,0.0001165065,0.01352932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01342385,"threshold_uncertainty_score":0.04490727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04216435730755914,"score_gpt":0.3869995978362735,"score_spread":0.3448352405287144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}