{"id":"W4386277907","doi":"10.1016/s2152-2650(23)00548-7","title":"POSTER: CML-313 Post Hoc Analysis of Patient Responses by T315I Mutation Status From the 3-Year Update of the OPTIC Trial: A Dose-Optimization Study of 3 Starting Doses of Ponatinib","year":2023,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Ponatinib; Post-hoc analysis; Medicine; Post hoc; Oncology; Internal medicine; Pharmacology; Imatinib","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004633833,0.0008544844,0.001928938,0.0002716294,0.000491148,0.001138318,0.0006719319,0.001193783,0.02042931],"category_scores_gemma":[0.006069238,0.0003367142,0.002593925,0.0002896434,0.0005052225,0.000815622,0.0004914599,0.002697332,0.003675174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001031507,"about_ca_system_score_gemma":0.001358904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007897749,"about_ca_topic_score_gemma":0.002455499,"domain_scores_codex":[0.9983314,0.001024569,0.0000875862,0.000225339,0.0001711407,0.0001599729],"domain_scores_gemma":[0.996612,0.001532297,0.0005458814,0.0003797077,0.0003192234,0.0006108854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8494908,0.003392817,0.004577506,0.0005235195,0.00263395,0.00007827472,0.00008733325,0.001990837,0.005213801,0.0002812897,0.06258709,0.06914275],"study_design_scores_gemma":[0.5830074,0.2277819,0.09263846,0.0002782281,0.006842103,0.0004823752,0.0001445968,0.005662174,0.01002049,0.002377334,0.07053468,0.0002301838],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8673089,0.007244853,0.005263964,0.01700217,0.004790613,0.008098204,0.05224947,0.001073947,0.03696788],"genre_scores_gemma":[0.9223434,0.002065823,0.006126816,0.01025515,0.002197751,0.004403387,0.02339458,0.0004777104,0.02873535],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02042931,"threshold_uncertainty_score":0.06834286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03539221462855332,"score_gpt":0.3543851135315048,"score_spread":0.3189928989029515,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}