{"id":"W4386277964","doi":"10.1016/s2152-2650(23)01136-9","title":"CML-319 Molecular Response of ≤10% BCR::ABL1IS Is Predictive of Positive Outcomes in Patients With Treatment-Resistant Chronic-Phase Chronic Myeloid Leukemia (CP-CML) Treated With Ponatinib From the Phase 2 OPTIC Trial","year":2023,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Ponatinib; Myeloid leukemia; Medicine; Oncology; Internal medicine; Immunology; Dasatinib; Cancer research; Imatinib","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001297506,0.0004340771,0.0008336497,0.0002125738,0.0003240776,0.0009717557,0.0003962158,0.0005909436,0.002637751],"category_scores_gemma":[0.001599114,0.0001498271,0.0008683308,0.0003864983,0.0003530503,0.0008021188,0.0004809356,0.001102575,0.0004678502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004731545,"about_ca_system_score_gemma":0.0004948676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003997314,"about_ca_topic_score_gemma":0.001330128,"domain_scores_codex":[0.9995622,0.0001755625,0.00003824023,0.00007419391,0.00006982841,0.00007994658],"domain_scores_gemma":[0.999084,0.0002032994,0.0003020369,0.00006109699,0.00007202749,0.0002774796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2607009,0.001830971,0.5922855,0.0007118654,0.002354576,0.0002900342,0.0002118987,0.002573743,0.015442,0.0006709098,0.01211793,0.1108098],"study_design_scores_gemma":[0.0272749,0.0240015,0.9238297,0.0001207909,0.002127129,0.001198912,0.0001902415,0.002898011,0.003051092,0.001529674,0.01370493,0.00007316468],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945234,0.001070403,0.0001198726,0.0004524252,0.00005292472,0.00009446132,0.001552485,0.00001965067,0.002114467],"genre_scores_gemma":[0.995359,0.0003933062,0.0001872841,0.0002854046,0.00008395129,0.00007493512,0.003090054,0.000007438604,0.0005185992],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002637751,"threshold_uncertainty_score":0.00882411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02052534718663807,"score_gpt":0.3262622600850023,"score_spread":0.3057369128983642,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}