{"id":"W4386279645","doi":"10.1126/scitranslmed.abo1557","title":"A blood-based marker of mitochondrial DNA damage in Parkinson’s disease","year":2023,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital","funders":"National Center for Advancing Translational Sciences; National Institutes of Health; National Institute on Aging; UK Research and Innovation; Medical Research Council; Biogen; National Health and Medical Research Council; Parkinson's Foundation; University of Pittsburgh; National Institute of Neurological Disorders and Stroke; Sanofi; Michael J. Fox Foundation for Parkinson's Research","keywords":"Mitochondrial DNA; LRRK2; DNA damage; Biology; Neuroprotection; Disease; Parkinson's disease; Mitochondrion; Pathogenesis; Mutation; Molecular biology; Pathology; Medicine; Genetics; Immunology; Gene; DNA; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005223685,0.0005107733,0.0004318348,0.001163529,0.0002114242,0.0004375444,0.0002929547,0.0007855967,0.0009684662],"category_scores_gemma":[0.0005511543,0.0002139891,0.0001543074,0.0005663956,0.0003235876,0.0002795695,0.0003076383,0.0006588359,0.0003806734],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001844598,"about_ca_system_score_gemma":0.0001709088,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002340287,"about_ca_topic_score_gemma":0.0005489138,"domain_scores_codex":[0.9994059,0.0001512155,0.00006111296,0.0001608013,0.0001791809,0.00004181886],"domain_scores_gemma":[0.9996564,0.0000741688,0.0001244625,0.00002489806,0.00006870006,0.00005146535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004651118,0.0001025171,0.007423548,0.0002665887,0.0000351294,0.0001535723,0.0001041649,0.0001335837,0.9770488,0.0001432814,0.0002188831,0.01390476],"study_design_scores_gemma":[0.00007125903,0.002683197,0.0839082,0.0001620811,0.0001524348,0.002723664,0.0001780008,0.003073978,0.898251,0.000588991,0.008167607,0.00003962624],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8825711,0.03499683,0.07326085,0.0003562341,0.0002295031,0.0003563269,0.003046868,0.0006096843,0.004572657],"genre_scores_gemma":[0.9395193,0.006293627,0.04765874,0.000279133,0.00009154439,0.00041421,0.002033174,0.00003385131,0.003676544],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001163529,"threshold_uncertainty_score":0.00323981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02570286541452128,"score_gpt":0.3008783551188966,"score_spread":0.2751754897043753,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}