{"id":"W4386279910","doi":"10.1523/jneurosci.0967-23.2023","title":"Cholinergic Reinforcement Signaling Is Impaired by Amyloidosis Prior to Its Synaptic Loss","year":2023,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; National Institute on Aging; National Institutes of Health; William and Ella Owens Medical Research Foundation; McGill University; Johns Hopkins University","keywords":"Cholinergic; Acetylcholine; Neuroscience; Amyloidosis; Cholinergic neuron; Psychology; Internal medicine; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002182144,0.000520963,0.0004093148,0.0005521333,0.0001831689,0.0004806611,0.0002355287,0.0005031814,0.0006301302],"category_scores_gemma":[0.0003438108,0.0002621648,0.0003771431,0.00014973,0.0004161036,0.0004037022,0.0003404211,0.001006466,0.0002291494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002803392,"about_ca_system_score_gemma":0.0001788408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007458786,"about_ca_topic_score_gemma":0.001032428,"domain_scores_codex":[0.9997223,0.00002132117,0.00003389958,0.0000701732,0.00009279999,0.00005955057],"domain_scores_gemma":[0.9993838,0.00004771611,0.0002831043,0.00004715224,0.0000820019,0.0001562566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001784349,0.00004137805,0.002113941,0.0000215746,0.00001094007,0.0002209395,0.00003762333,0.00003670699,0.9961547,0.00006530275,0.00001933194,0.001099076],"study_design_scores_gemma":[0.00002205078,0.001066324,0.1180745,0.0000257905,0.00006130559,0.001842562,0.0001374207,0.001013964,0.8765867,0.0002896699,0.0008625236,0.0000171242],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973006,0.0005580079,0.00117134,0.0000260857,0.00001216098,0.0000118584,0.0001700365,0.00006587718,0.0006840667],"genre_scores_gemma":[0.9969236,0.0004475316,0.001050084,0.00003887193,0.000005714695,0.00002386113,0.0002045105,0.00001967174,0.001286148],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007458786,"threshold_uncertainty_score":0.002108037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04560523087224746,"score_gpt":0.3257264689439103,"score_spread":0.2801212380716629,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}