{"id":"W4386282130","doi":"10.1016/s2152-2650(23)01510-0","title":"CT-356 Idecabtagene Vicleucel (ide-cel) Versus Standard Regimens in Patients With Triple-Class–Exposed (TCE) Relapsed and Refractory Multiple Myeloma (RRMM): KarMMa-3, a Phase III Randomized Controlled Trial (RCT)","year":2023,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Cancer Research; University of Calgary","funders":"","keywords":"Randomized controlled trial; Medicine; Refractory (planetary science); Internal medicine; Multiple myeloma; Oncology; Materials science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001474494,0.001361009,0.002810911,0.0003689723,0.000409304,0.001036084,0.0007317184,0.001326701,0.007307277],"category_scores_gemma":[0.001640457,0.0005606491,0.002450908,0.0004572275,0.000991164,0.001056425,0.0004396972,0.003856679,0.0009120909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008736599,"about_ca_system_score_gemma":0.0009363849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001916789,"about_ca_topic_score_gemma":0.003531895,"domain_scores_codex":[0.9992949,0.0003758316,0.00004484685,0.0001330884,0.00004378971,0.0001076094],"domain_scores_gemma":[0.9991855,0.000260516,0.0002046958,0.00006186021,0.00004611094,0.0002413017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9844984,0.00241065,0.0005126382,0.0006378143,0.001838841,0.00001866856,0.00003220701,0.0001824,0.0008979458,0.0000806735,0.0004767501,0.008413021],"study_design_scores_gemma":[0.95224,0.04348875,0.001658662,0.0000647566,0.001441889,0.00002588198,0.00002649997,0.0002311381,0.0002181608,0.000128095,0.0004654955,0.0000106309],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9811432,0.01079261,0.0005586928,0.0008445476,0.0007038272,0.00198733,0.001065136,0.0001456875,0.002758882],"genre_scores_gemma":[0.9916068,0.002716084,0.0009165516,0.000842308,0.0002761214,0.001231833,0.0006318701,0.00001634988,0.001762018],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007307277,"threshold_uncertainty_score":0.0244453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03342291975755474,"score_gpt":0.3387249983998634,"score_spread":0.3053020786423086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}