{"id":"W4386282152","doi":"10.1016/s2152-2650(23)01190-4","title":"MDS-460 Efficacy of Pacritinib for Spleen, Symptoms, and Anemia Benefit in Myelofibrosis Patients Across the Cytopenic Spectrum","year":2023,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Myelofibrosis; Ruxolitinib; Medicine; Anemia; Spleen; Pediatrics; Internal medicine; Bone marrow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003482155,0.0002434797,0.0006703042,0.0002194458,0.0002097101,0.0005234603,0.0001668563,0.0001898502,0.002752003],"category_scores_gemma":[0.0004533745,0.0001065753,0.0005092087,0.0002005266,0.0001407829,0.0002990242,0.0001765338,0.0007716009,0.0003129307],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005352594,"about_ca_system_score_gemma":0.0004457063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007292211,"about_ca_topic_score_gemma":0.003163831,"domain_scores_codex":[0.9998803,0.00003314525,0.000008680247,0.0000176685,0.00002483312,0.00003534113],"domain_scores_gemma":[0.999859,0.00002509284,0.00003120104,0.000006948322,0.00001586158,0.00006188267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1177302,0.003554049,0.076204,0.0009426265,0.002221997,0.0007833003,0.0002484153,0.004106498,0.04057382,0.002383678,0.0155613,0.73569],"study_design_scores_gemma":[0.09852862,0.1223472,0.6569335,0.0008592652,0.004502668,0.008389262,0.0005168038,0.009613486,0.01731972,0.004399197,0.0764431,0.0001472915],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9742379,0.01335047,0.0002275598,0.0008968309,0.00009192721,0.0001141587,0.000657113,0.00006442376,0.01035963],"genre_scores_gemma":[0.9952485,0.002129597,0.0003639675,0.0004960057,0.00008983613,0.00004971534,0.0006988647,0.000006885574,0.0009167267],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002752003,"threshold_uncertainty_score":0.009206355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02972178219280005,"score_gpt":0.3497908632459027,"score_spread":0.3200690810531027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}