{"id":"W4386282271","doi":"10.1016/s2152-2650(23)00661-4","title":"POSTER: MPN-524 Reductions in Indolent Systemic Mastocytosis Biomarker Burden With Avapritinib in the Registrational, Double-Blind, Placebo-Controlled PIONEER Trial","year":2023,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; University of Calgary","funders":"","keywords":"Systemic mastocytosis; Double blind; Medicine; Placebo; Biomarker; Internal medicine; Pathology; Biology; Alternative medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001269902,0.001301386,0.002346997,0.0002430115,0.0004130944,0.00100065,0.0006807003,0.001809566,0.01527881],"category_scores_gemma":[0.001280745,0.0004017892,0.002068754,0.0001976087,0.0005976663,0.0008760673,0.0002668038,0.003746508,0.002325497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005940942,"about_ca_system_score_gemma":0.0006663371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000671673,"about_ca_topic_score_gemma":0.001673809,"domain_scores_codex":[0.9996755,0.0001226031,0.00001867553,0.00007095509,0.00003738343,0.0000748169],"domain_scores_gemma":[0.9995157,0.0001321882,0.0001063461,0.00003713507,0.00004858731,0.0001600466],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8929011,0.002900266,0.0005586745,0.0028342,0.002569508,0.0000696499,0.00005865837,0.0004706306,0.00783573,0.000336412,0.0185754,0.07088979],"study_design_scores_gemma":[0.9386874,0.04760774,0.005266058,0.0001502118,0.00123229,0.00008581163,0.00002865609,0.0003375536,0.001258589,0.0003268089,0.00498092,0.00003795128],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.88493,0.06399556,0.002396423,0.009708498,0.007300989,0.004279129,0.008589108,0.001452502,0.01734778],"genre_scores_gemma":[0.9542152,0.01316512,0.001951732,0.005343257,0.002650964,0.001993634,0.00334552,0.0001132871,0.01722124],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01527881,"threshold_uncertainty_score":0.05111271,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06310151596938657,"score_gpt":0.3214162376218272,"score_spread":0.2583147216524406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}