{"id":"W4386282375","doi":"10.1016/s2152-2650(23)01134-5","title":"CML-313 Post Hoc Analysis of Patient Responses by T315I Mutation Status From the 3-Year Update of the OPTIC Trial: A Dose-Optimization Study of 3 Starting Doses of Ponatinib","year":2023,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Ponatinib; Medicine; Post hoc; Post-hoc analysis; Mutation; Oncology; Internal medicine; Genetics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007294093,0.001256607,0.003797976,0.0004137081,0.0004457403,0.001521458,0.00109804,0.001092113,0.005552439],"category_scores_gemma":[0.00514717,0.0004779591,0.004228287,0.0006067092,0.0009174883,0.001670016,0.0006832553,0.003093894,0.001085192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001106783,"about_ca_system_score_gemma":0.00141725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009884947,"about_ca_topic_score_gemma":0.002481754,"domain_scores_codex":[0.9960443,0.002524825,0.000150003,0.0005414419,0.0002947038,0.0004448406],"domain_scores_gemma":[0.9962147,0.001793419,0.0006533119,0.0007185533,0.0002079527,0.0004120599],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.957623,0.001849277,0.008819041,0.0001884284,0.004139314,0.00005054351,0.00009338128,0.002697784,0.003720267,0.0001686861,0.003162552,0.01748762],"study_design_scores_gemma":[0.4141994,0.2937094,0.2276423,0.0001066737,0.01541725,0.0005685285,0.0003763305,0.02107975,0.009968194,0.002062321,0.01460989,0.0002599521],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907988,0.001031787,0.001019016,0.0002925642,0.000126172,0.0006269647,0.003373206,0.0001234813,0.002608034],"genre_scores_gemma":[0.9909848,0.0002410035,0.001071312,0.0003551469,0.0001079393,0.000665097,0.004215122,0.00008199536,0.002277594],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007294093,"threshold_uncertainty_score":0.03857529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03633673717965375,"score_gpt":0.3577375740051628,"score_spread":0.321400836825509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}