{"id":"W4386283244","doi":"10.3390/pathogens12091109","title":"Mycobacterium tuberculosis Central Metabolism Is Key Regulator of Macrophage Pyroptosis and Host Immunity","year":2023,"lang":"en","type":"article","venue":"Pathogens","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Institute of Allergy and Infectious Diseases; Center for AIDS Research, University of Washington; National Institutes of Health","keywords":"Pyroptosis; Mycobacterium tuberculosis; Mycobacterium bovis; Biology; Virulence; Microbiology; Transposable element; Tuberculosis; Macrophage; Pathogen; Mycobacterium; Gene; Inflammasome; Immunology; Mutant; Genetics; Inflammation; Medicine; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001437525,0.0002218447,0.0002327274,0.0002101586,0.0001184956,0.0002690484,0.0001026948,0.0002058495,0.0008301937],"category_scores_gemma":[0.0001199259,0.00008321363,0.0001612085,0.0001506981,0.0001307133,0.0001227652,0.0001972004,0.0002375854,0.0002360892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002108696,"about_ca_system_score_gemma":0.0001833666,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003070143,"about_ca_topic_score_gemma":0.0003622582,"domain_scores_codex":[0.9998797,0.00002527937,0.000009141412,0.00002870468,0.00002990806,0.00002723937],"domain_scores_gemma":[0.9999021,0.00001167938,0.00003748828,0.000007739796,0.00001350812,0.00002744496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001564192,0.00001674336,0.003282689,0.00003157852,0.000003817703,0.00008552424,0.00001023628,0.00003322946,0.9945779,0.00005227563,0.00001806335,0.001731655],"study_design_scores_gemma":[0.00002915119,0.0008429263,0.3114415,0.00002600417,0.00004448809,0.002494038,0.0001606334,0.001399879,0.6793076,0.0003855521,0.00385157,0.00001670558],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931217,0.003589207,0.001788703,0.00009925022,0.00001155401,0.00001693839,0.0002889665,0.00004187493,0.001041795],"genre_scores_gemma":[0.9975324,0.0006572919,0.0009006535,0.00002581293,0.000005702202,0.000008069648,0.0002298208,0.000003616298,0.0006365629],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008301937,"threshold_uncertainty_score":0.002777278,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02110958293172718,"score_gpt":0.291898921835329,"score_spread":0.2707893389036018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}