{"id":"W4386283244","doi":"10.3390/pathogens12091109","title":"Mycobacterium tuberculosis Central Metabolism Is Key Regulator of Macrophage Pyroptosis and Host Immunity","year":2023,"lang":"en","type":"article","venue":"Pathogens","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Institute of Allergy and Infectious Diseases; Center for AIDS Research, University of Washington; National Institutes of Health","keywords":"Pyroptosis; Mycobacterium tuberculosis; Mycobacterium bovis; Biology; Virulence; Microbiology; Transposable element; Tuberculosis; Macrophage; Pathogen; Mycobacterium; Gene; Inflammasome; Immunology; Mutant; Genetics; Inflammation; Medicine; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006208856,0.0002186997,0.0006811253,0.0002574446,0.0001132456,0.00001352006,0.0001273484,0.0001907824,0.0004166795],"category_scores_gemma":[0.0007264626,0.0001823698,0.0002299635,0.0005948571,0.000238364,0.00007391536,0.0002188118,0.000299516,0.0001140711],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004245161,"about_ca_system_score_gemma":0.00006854577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004903564,"about_ca_topic_score_gemma":0.00001307605,"domain_scores_codex":[0.9978473,0.00025495,0.0004321887,0.0003742747,0.0003038422,0.0007874581],"domain_scores_gemma":[0.9985043,0.0001984154,0.00009022524,0.0005706049,0.0001551858,0.0004812251],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002254673,0.0001170304,0.1410631,0.0002952823,0.0003509278,0.00007544285,0.001272819,9.963682e-7,0.8459687,0.0002026898,0.007545395,0.002882184],"study_design_scores_gemma":[0.0007551641,0.0001419373,0.9086837,0.00004621119,0.0001877328,0.00004750802,0.0002524752,0.0002756068,0.0817652,0.00007881641,0.007611391,0.0001542117],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927694,0.001425428,0.000008686853,0.004048503,0.0001755479,0.0003079363,0.0004827719,0.0001022209,0.0006795485],"genre_scores_gemma":[0.9932869,0.004650118,0.000516296,0.0006810304,0.000184243,0.0000289358,0.00009800951,0.00003978949,0.0005146841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7676206,"threshold_uncertainty_score":0.7436823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02110958293172718,"score_gpt":0.291898921835329,"score_spread":0.2707893389036018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}