{"id":"W4386286221","doi":"10.21203/rs.3.rs-3290507/v1","title":"Lactic Acid Enhances Vaginal Epithelial Barrier Integrity and Ameliorates Inflammatory Effects of Dysbiotic Short Chain Fatty Acids and HIV-1","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Reproductive tract infections research","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Dysbiosis; Lactobacillus; Microbiology; Inflammation; Chemokine; Clostridium difficile toxin A; Short-chain fatty acid; Biology; Chemistry; Immunology; Bacteria; Clostridium difficile; Biochemistry; Gut flora; Butyrate","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001333942,0.0002397424,0.0003203716,0.0002014965,0.0001211244,0.0003364073,0.0001989793,0.0002515652,0.001482265],"category_scores_gemma":[0.0001198092,0.00009941783,0.0002245765,0.0001503433,0.0001103602,0.0001778545,0.0002442409,0.0005735945,0.0001433814],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001124518,"about_ca_system_score_gemma":0.0001858963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004836801,"about_ca_topic_score_gemma":0.0009245727,"domain_scores_codex":[0.9998513,0.00004557849,0.00001256987,0.00001585379,0.00003592753,0.00003876661],"domain_scores_gemma":[0.9999397,0.000008216713,0.00001471561,0.000005326806,0.00001152368,0.00002050044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001064707,0.000331457,0.0004053215,0.0001658639,0.00001688322,0.00005799434,0.00002259986,0.00005815706,0.9911834,0.00004439132,0.00007792546,0.006571319],"study_design_scores_gemma":[0.0001136744,0.008260919,0.01694626,0.00008827437,0.00008071602,0.0003474114,0.000207359,0.0009596872,0.9650472,0.0001064645,0.007831188,0.00001082115],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897439,0.00807862,0.0007191093,0.0001391564,0.00006155312,0.00004047029,0.0002232241,0.00003692024,0.0009570227],"genre_scores_gemma":[0.9938306,0.002519452,0.001433883,0.0001118755,0.00002072663,0.00003547966,0.0003246386,0.000008310097,0.001715058],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001482265,"threshold_uncertainty_score":0.004958689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0408124829307903,"score_gpt":0.3658630492694874,"score_spread":0.3250505663386971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}