{"id":"W4386292522","doi":"10.3389/fimmu.2023.1173634","title":"Heparins are potent inhibitors of ectonucleotide pyrophosphatase/phospho-diesterase-1 (NPP1) – a promising target for the immunotherapy of cancer","year":2023,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft","keywords":"Pyrophosphatase; Medicine; Cancer; Polyphosphate; Cancer research; Immunotherapy; Pharmacology; Chemistry; Biochemistry; Internal medicine; Enzyme; Phosphate","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001613557,0.0003878004,0.000170617,0.0001539898,0.00008129017,0.0001975765,0.0001564486,0.0002279168,0.001493309],"category_scores_gemma":[0.0001176339,0.00008742277,0.0001465651,0.0001419053,0.000149258,0.0001046423,0.0001172249,0.0004407892,0.000386472],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001495408,"about_ca_system_score_gemma":0.0001495318,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002142858,"about_ca_topic_score_gemma":0.0003655236,"domain_scores_codex":[0.9999189,0.00001896969,0.000005733833,0.00001519344,0.00002806504,0.0000131315],"domain_scores_gemma":[0.9999524,0.00001197324,0.0000159698,0.000003273137,0.000006450991,0.000009860499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001386269,0.00006471453,0.0003408797,0.0001987122,0.00001634151,0.00005568966,0.00001014442,0.0001570725,0.9790475,0.000400187,0.0002666987,0.01930336],"study_design_scores_gemma":[0.00004873783,0.0009447418,0.002935889,0.00001544925,0.00002408477,0.0004556798,0.000008582693,0.0005219975,0.9767748,0.0001590995,0.018105,0.000005958227],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8298551,0.1308952,0.02466904,0.0009272149,0.0002848143,0.000230328,0.001128389,0.0002546258,0.01175528],"genre_scores_gemma":[0.9627244,0.0231441,0.007213677,0.0002495893,0.0001200583,0.00008329253,0.001035954,0.00001953037,0.00540935],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001493309,"threshold_uncertainty_score":0.004995584,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008547694368096175,"score_gpt":0.2474396788349206,"score_spread":0.2388919844668244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}