{"id":"W4386292835","doi":"10.7717/peerj.15961","title":"Regulation of HDAC11 gene expression in early myogenic differentiation","year":2023,"lang":"en","type":"article","venue":"PeerJ","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Umm Al-Qura University","keywords":"MyoD; HDAC11; Myogenesis; Biology; MYF5; HDAC4; Histone; Cellular differentiation; Regulation of gene expression; Histone acetyltransferase; Cell biology; Histone deacetylase; Histone deacetylase 5; Myogenic regulatory factors; Gene expression; Myocyte; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001729121,0.00006067484,0.00008138358,0.0001215627,0.00002448418,0.000005561029,0.00008486496,0.00009536348,0.00002067964],"category_scores_gemma":[0.00009637137,0.00006174692,0.00004590792,0.0002040213,0.00002594337,0.000003265638,0.00007199571,0.00005070331,0.00003743537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001769793,"about_ca_system_score_gemma":0.00002781494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002508391,"about_ca_topic_score_gemma":0.00003014607,"domain_scores_codex":[0.9992633,0.00005624001,0.0001598224,0.0001852687,0.0001915632,0.0001437775],"domain_scores_gemma":[0.9996322,0.000009250693,0.00004797956,0.0002202331,0.00005933586,0.00003096998],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003780403,0.00002307532,0.005947088,0.0000126269,0.000003972419,0.000001261039,0.0001142294,0.0001319995,0.9917666,0.00000614439,0.001379475,0.0005757134],"study_design_scores_gemma":[0.000251155,0.00004505129,0.2216627,0.00001027096,0.000001485675,7.097447e-7,0.00001045734,0.0002438531,0.7773694,0.00003545296,0.0003212212,0.00004825102],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991693,0.00009507019,0.000313783,0.00005597111,0.00006982912,0.0001109709,0.000009849932,0.00001250659,0.0001626506],"genre_scores_gemma":[0.997708,0.00003849901,0.0001606081,0.000004313564,0.00008376255,0.0000124296,0.0002941098,0.00001308914,0.001685195],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2157156,"threshold_uncertainty_score":0.2517966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01406658310195169,"score_gpt":0.2757291197319353,"score_spread":0.2616625366299836,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}