{"id":"W4386292835","doi":"10.7717/peerj.15961","title":"Regulation of HDAC11 gene expression in early myogenic differentiation","year":2023,"lang":"en","type":"article","venue":"PeerJ","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Umm Al-Qura University","keywords":"MyoD; HDAC11; Myogenesis; Biology; MYF5; HDAC4; Histone; Cellular differentiation; Regulation of gene expression; Histone acetyltransferase; Cell biology; Histone deacetylase; Histone deacetylase 5; Myogenic regulatory factors; Gene expression; Myocyte; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001792633,0.0003110114,0.000306834,0.0003337477,0.0003561141,0.0005389477,0.0002324779,0.0002817613,0.00271458],"category_scores_gemma":[0.0001478066,0.0002534017,0.0003275912,0.0002505792,0.0003541199,0.0003001785,0.0003644154,0.0005998762,0.001349235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006543448,"about_ca_system_score_gemma":0.0004052503,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001505987,"about_ca_topic_score_gemma":0.003424356,"domain_scores_codex":[0.9997472,0.00002240613,0.00001818072,0.00008302846,0.00006370318,0.00006529519],"domain_scores_gemma":[0.9998808,0.00001468906,0.00002354964,0.00001315346,0.00003298162,0.00003470773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008651106,0.00001124445,0.001090704,0.00006990802,0.000004934912,0.00006185556,0.0000337343,0.00003462589,0.9945045,0.0004447332,0.0001467452,0.003510466],"study_design_scores_gemma":[0.00001237018,0.00008994839,0.02989523,0.00001770517,0.00002311924,0.0002975687,0.0001032677,0.0005507813,0.9496849,0.0001363112,0.01917844,0.00001042424],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9325712,0.01589266,0.02357682,0.000453668,0.0003680245,0.0001429489,0.003568501,0.0004844844,0.02294168],"genre_scores_gemma":[0.9659325,0.004990241,0.006761812,0.0001874447,0.00005459964,0.00006753502,0.002401885,0.0001136437,0.01949037],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00271458,"threshold_uncertainty_score":0.009081185,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01406658310195169,"score_gpt":0.2757291197319353,"score_spread":0.2616625366299836,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}