{"id":"W4386306432","doi":"10.1093/dote/doad052.188","title":"384. ROBUST CULTURE OF PATIENT-DERIVED ESOPHAGEAL ADENOCARCINOMA ORGANOIDS OF SINGLE CELL LINEAGE","year":2023,"lang":"en","type":"article","venue":"Diseases of the Esophagus","topic":"Esophageal Cancer Research and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Organoid; Matrigel; DAPI; Cell culture; Cell; Single-cell analysis; Biology; Pathology; Cell biology; Medicine; Staining","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000537584,0.0003855424,0.0004932219,0.0003487323,0.0003283444,0.0005448685,0.0004074431,0.0004315414,0.002988171],"category_scores_gemma":[0.000311079,0.0002558532,0.0006302813,0.000358869,0.0001776826,0.0002187437,0.0004760605,0.0007002208,0.003419313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003327822,"about_ca_system_score_gemma":0.0003018038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001031448,"about_ca_topic_score_gemma":0.001605752,"domain_scores_codex":[0.9995332,0.0000623184,0.00007410506,0.0001226556,0.0001619984,0.00004571964],"domain_scores_gemma":[0.9996316,0.00007792699,0.00003684811,0.0001173259,0.00008750003,0.00004873934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007277342,0.00003171776,0.0005610793,0.00009383468,0.00001068814,0.0002096803,0.00009580054,0.0003752168,0.9927739,0.0002140154,0.0005826119,0.004978782],"study_design_scores_gemma":[0.00002113611,0.000316085,0.005916662,0.00004888746,0.00005654422,0.001447658,0.0000720107,0.004107886,0.961383,0.0002055226,0.02640136,0.00002337018],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7599061,0.006778257,0.1892943,0.0006663856,0.0002692634,0.001188036,0.02056701,0.002106501,0.01922416],"genre_scores_gemma":[0.8290129,0.003246257,0.1171067,0.0003356864,0.00004020061,0.001373609,0.02536763,0.0004712474,0.02304575],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002988171,"threshold_uncertainty_score":0.009996414,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01670886432209815,"score_gpt":0.2568788481977742,"score_spread":0.240169983875676,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}