{"id":"W4386314066","doi":"10.1016/j.smim.2023.101837","title":"Thymus aging and immune reconstitution, progresses and challenges","year":2023,"lang":"en","type":"review","venue":"Seminars in Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sunnybrook Health Science Centre; Sunnybrook Hospital; University of Toronto","funders":"","keywords":"Thymic involution; Involution (esoterism); Biology; Immune system; Wnt signaling pathway; Thymocyte; Lymphopoiesis; Fibroblast growth factor; Immunology; Cell biology; Internal medicine; Endocrinology; Stem cell; T cell; Progenitor cell; Signal transduction; Medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001737125,0.001013627,0.002079905,0.001717497,0.0003431888,0.001761338,0.001183923,0.002186685,0.002815334],"category_scores_gemma":[0.001687044,0.0003060528,0.0004399824,0.001676383,0.001128947,0.002530508,0.001179777,0.003028935,0.001977692],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007627208,"about_ca_system_score_gemma":0.001268285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006046356,"about_ca_topic_score_gemma":0.001207431,"domain_scores_codex":[0.9997128,0.00006321847,0.00004200163,0.00005568878,0.00008769058,0.00003858627],"domain_scores_gemma":[0.9992526,0.0004266188,0.00007967904,0.00002344806,0.0001292946,0.00008838772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002594084,0.00008242256,0.0002674279,0.01058106,0.00007870563,0.0003066323,0.0000552822,0.0003306623,0.001105686,0.006541254,0.07203098,0.9083604],"study_design_scores_gemma":[0.00005684159,0.0001317476,0.001107079,0.004457206,0.0001483122,0.001847464,0.0001122105,0.0001437054,0.0003585335,0.005732752,0.9858743,0.00002992035],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003131791,0.9989737,0.00004397033,0.0003546641,0.0004182696,7.814419e-7,0.000004810485,0.000003401286,0.0001690437],"genre_scores_gemma":[0.0005051534,0.9968243,0.00009476802,0.0005015017,0.001733033,0.000004426192,0.00001522798,0.000001629071,0.000320034],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002815334,"threshold_uncertainty_score":0.009418249,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04789794623491268,"score_gpt":0.2939058382714589,"score_spread":0.2460078920365463,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}