{"id":"W4386315356","doi":"10.1038/s41467-023-41064-5","title":"Screening non-conventional yeasts for acid tolerance and engineering Pichia occidentalis for production of muconic acid","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University; Western University","funders":"Fonds Québécois de la Recherche sur la Nature et les Technologies; Concordia University; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Muconic acid; Pichia; Production (economics); Yeast; Chemistry; Biology; Biochemistry; Recombinant DNA; Pichia pastoris; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002216462,0.0008086752,0.000390119,0.0005420357,0.0002092898,0.0006273333,0.0003620806,0.0002607387,0.0009687205],"category_scores_gemma":[0.0003005579,0.0001513213,0.0003019768,0.0005175546,0.0001745641,0.0001977821,0.0005848447,0.0003719495,0.0005541251],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002196221,"about_ca_system_score_gemma":0.0002054695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001371387,"about_ca_topic_score_gemma":0.00326256,"domain_scores_codex":[0.9997488,0.00002564051,0.00002877991,0.0000627503,0.0001050987,0.00002903109],"domain_scores_gemma":[0.9998209,0.00003779383,0.0000452802,0.00003291768,0.00002955955,0.00003360145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002837608,0.00002614535,0.0004119621,0.00003491988,0.000004926679,0.00004451646,0.000009525374,0.00004850477,0.9975377,0.00001677239,0.00002543979,0.001811205],"study_design_scores_gemma":[0.000005419894,0.000320431,0.008756179,0.00001039719,0.00003108161,0.0002894858,0.0000572667,0.0005128231,0.9881589,0.0000243903,0.00182388,0.00000974794],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874372,0.0008854972,0.007043887,0.0001385317,0.00002693819,0.0001059998,0.00150927,0.000433422,0.002419235],"genre_scores_gemma":[0.9780397,0.001158616,0.0129549,0.00008237701,0.00001114602,0.00008582821,0.003740532,0.0001154399,0.003811513],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001371387,"threshold_uncertainty_score":0.003240705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01130020452945415,"score_gpt":0.2685976824991215,"score_spread":0.2572974779696673,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}