{"id":"W4386315538","doi":"10.1093/dote/doad052.224","title":"432. SINGLE-CELL RNA SEQUENCING OF MORPHOLOGICALLY-PURE PATIENT-DERIVED ORGANOIDS FROM ESOPHAGEAL ADENOCARCINOMA PATIENTS","year":2023,"lang":"en","type":"article","venue":"Diseases of the Esophagus","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Organoid; Matrigel; Morphology (biology); Cell; Single-cell analysis; Phenotype; Biology; RNA; Medicine; Gene; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003115296,0.0002358602,0.0003365571,0.0005230475,0.000303825,0.0005319004,0.0001562359,0.0002753573,0.001477169],"category_scores_gemma":[0.0005058342,0.0001526486,0.0004018787,0.0004366229,0.0001479737,0.0001113926,0.0001841904,0.0002943688,0.0008808966],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000200189,"about_ca_system_score_gemma":0.0002211014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007157049,"about_ca_topic_score_gemma":0.001300474,"domain_scores_codex":[0.9997007,0.00003766803,0.00004050743,0.000105463,0.00008667865,0.00002913195],"domain_scores_gemma":[0.9997125,0.00008476684,0.00003519402,0.00005245514,0.00008863035,0.00002644945],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001803622,0.0000192257,0.005746088,0.00006320004,0.00001992535,0.000194156,0.0001102239,0.0003134274,0.9862952,0.00005199858,0.0001906084,0.006815685],"study_design_scores_gemma":[0.00003851735,0.0007713321,0.09917067,0.00004007448,0.0001617351,0.003040419,0.0004815145,0.004967722,0.8722125,0.0001966176,0.0188885,0.00003034689],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9556993,0.00169572,0.02721244,0.0001685691,0.00006087001,0.0002495234,0.01178457,0.0002901642,0.002838913],"genre_scores_gemma":[0.9209678,0.00131274,0.04715545,0.0002396948,0.00002740482,0.0004689467,0.02503263,0.0002064431,0.004588859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001477169,"threshold_uncertainty_score":0.004941642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01773642838512064,"score_gpt":0.2224902860681018,"score_spread":0.2047538576829812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}