{"id":"W4386317887","doi":"10.1093/dote/doad052.107","title":"268. DEVELOPMENT OF A NOVEL ESOPHAGUS-ON-A-CHIP MODEL: A HIGH-FIDELITY PLATFORM FOR DIRECTING PERSONALIZED THERAPY IN ESOPHAGEAL ADENOCARCINOMA","year":2023,"lang":"en","type":"article","venue":"Diseases of the Esophagus","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Medicine; Chemotherapy; Esophagus; Docetaxel; Esophageal cancer; Pathology; Neoadjuvant therapy; Adenocarcinoma; Cancer research; Oncology; Internal medicine; Cancer; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004166803,0.0002958604,0.000722124,0.0002529011,0.0001293866,0.00001178178,0.0003054563,0.00008626329,0.00003511044],"category_scores_gemma":[0.0002718906,0.0002156292,0.0004861803,0.0006178432,0.0001318028,0.00007328648,0.0001133244,0.0001561697,0.00000314071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001699807,"about_ca_system_score_gemma":0.0005742753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001538564,"about_ca_topic_score_gemma":0.00002896849,"domain_scores_codex":[0.9978005,0.00003016226,0.0006993946,0.000438541,0.0005888781,0.0004425794],"domain_scores_gemma":[0.9985345,0.0002927731,0.0003054263,0.0005262703,0.0001649848,0.0001760488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02737615,0.00723251,0.8196896,0.003340096,0.001929571,0.00009617997,0.01205029,0.01427385,0.00456609,0.004800691,0.002236041,0.102409],"study_design_scores_gemma":[0.0175574,0.0004526138,0.8883355,0.0005941434,0.0002704457,0.000006880651,0.0005004666,0.01482496,0.07603519,0.00102099,0.00002734045,0.0003740244],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9475403,0.04956437,0.0003015437,0.000237797,0.0002979241,0.001447695,0.0005097291,0.0000789914,0.00002164381],"genre_scores_gemma":[0.9958729,0.0001161193,0.002943213,0.0002768147,0.0001140918,0.0002599383,0.00007483728,0.00005714707,0.0002849236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1020349,"threshold_uncertainty_score":0.8793102,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06373962546171925,"score_gpt":0.3165465519529896,"score_spread":0.2528069264912703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}