{"id":"W4386318191","doi":"10.1093/dote/doad052.187","title":"383. DEVELOPMENT OF PERSONALIZED ‘LIQUID BIOPSY’ FOR ESOPHAGEAL ADENOCARCINOMA FROM MATCHED ORGANOID CULTURE","year":2023,"lang":"en","type":"article","venue":"Diseases of the Esophagus","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Micrococcal nuclease; Liquid biopsy; Nucleosome; DNA; Medicine; Buccal swab; Molecular biology; Chromatin; Biology; Genetics; Cancer; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005982835,0.0003683058,0.00031112,0.0002981989,0.0003398191,0.0004699819,0.000564741,0.0004631567,0.004350909],"category_scores_gemma":[0.0003676614,0.0002813819,0.000455854,0.0002187629,0.0002094717,0.0002881401,0.0004878932,0.0005072835,0.004000685],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002696231,"about_ca_system_score_gemma":0.0003555256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001763285,"about_ca_topic_score_gemma":0.003802456,"domain_scores_codex":[0.9996319,0.00005627526,0.00003609931,0.0001141985,0.0001291792,0.00003237842],"domain_scores_gemma":[0.9996867,0.00006794617,0.00003264115,0.00007548686,0.0000861372,0.00005101947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006602229,0.00003013674,0.0007547325,0.00006140424,0.000008715828,0.0001773013,0.00004595874,0.000289359,0.9912777,0.000169395,0.0004281369,0.006691134],"study_design_scores_gemma":[0.00001871777,0.0003587419,0.006005377,0.00004208633,0.00003816594,0.0008932267,0.00007120613,0.005130925,0.9653394,0.000150712,0.02192798,0.00002346806],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.6012847,0.003317798,0.356312,0.0005886873,0.0003425678,0.001833342,0.008881725,0.002045466,0.02539365],"genre_scores_gemma":[0.660864,0.001928782,0.2959224,0.0005373972,0.00004531394,0.00120136,0.01712927,0.0003476901,0.02202371],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.004350909,"threshold_uncertainty_score":0.01455522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01058076211840581,"score_gpt":0.2476976080561935,"score_spread":0.2371168459377877,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}