{"id":"W4386318293","doi":"10.1093/dote/doad052.165","title":"352. GENERATION OF PATIENT-DERIVED ESOPHAGEAL ADENOCARCINOMA ORGANOIDS FROM CIRCULATING TUMOR CELLS","year":2023,"lang":"en","type":"article","venue":"Diseases of the Esophagus","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Organoid; Circulating tumor cell; Matrigel; DAPI; Pathology; Medicine; Cancer research; Immunomagnetic separation; Molecular biology; Cancer; Biology; Cell biology; Internal medicine; Metastasis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003187623,0.0002983209,0.0003231757,0.0002212995,0.0001878535,0.0003951706,0.0002571268,0.0003306211,0.002430369],"category_scores_gemma":[0.0002229518,0.0001795578,0.0004359164,0.0002125608,0.0001290807,0.0001289417,0.0003433962,0.0005911576,0.001757292],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002199077,"about_ca_system_score_gemma":0.0002124336,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007881852,"about_ca_topic_score_gemma":0.001141714,"domain_scores_codex":[0.9997975,0.00003175839,0.00002563757,0.00005707593,0.00005652837,0.00003154119],"domain_scores_gemma":[0.9998057,0.00003463325,0.00002360875,0.00004484551,0.00004025497,0.00005090088],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001793204,0.00004840315,0.0008219826,0.00009029525,0.00001291687,0.0002221696,0.0000966485,0.0005134029,0.9935426,0.0001787167,0.0004731723,0.003820387],"study_design_scores_gemma":[0.00006568265,0.0009244744,0.009175574,0.00005169817,0.00006443238,0.001466315,0.0001162986,0.006077639,0.9595273,0.0001366931,0.0223633,0.00003068161],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9260674,0.002549224,0.05241859,0.000275043,0.0001847615,0.0008968124,0.008607748,0.0007014784,0.008298869],"genre_scores_gemma":[0.9434537,0.0009421556,0.03239256,0.0001601833,0.00001690087,0.0006028657,0.01234716,0.00009759841,0.009987013],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002430369,"threshold_uncertainty_score":0.008130431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02042532024629938,"score_gpt":0.2436012669623926,"score_spread":0.2231759467160932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}