{"id":"W4386318621","doi":"10.1053/j.gastro.2023.08.038","title":"Guselkumab in Patients With Moderately to Severely Active Ulcerative Colitis: QUASAR Phase 2b Induction Study","year":2023,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University of British Columbia; McGill University Health Centre","funders":"Janssen Research and Development; Janssen Scientific Affairs","keywords":"Medicine; Placebo; Clinical endpoint; Internal medicine; Gastroenterology; Ulcerative colitis; Clinical trial; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001671329,0.0006884312,0.001585177,0.0002352767,0.0002225561,0.0004569702,0.000452411,0.0005726424,0.002299581],"category_scores_gemma":[0.0004904119,0.0003294246,0.0008343335,0.0002037376,0.0005453161,0.0004007815,0.0002464313,0.001634295,0.0004568807],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002834331,"about_ca_system_score_gemma":0.0006511752,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002485775,"about_ca_topic_score_gemma":0.0008507322,"domain_scores_codex":[0.9996554,0.0001852835,0.00001947446,0.00003562736,0.00004216602,0.00006209024],"domain_scores_gemma":[0.9996219,0.00007264105,0.00009754863,0.00002630965,0.0000290134,0.0001526107],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.623358,0.06297487,0.01437837,0.001937319,0.001886357,0.0004949161,0.0002890292,0.001509727,0.1137062,0.0004306051,0.004116189,0.1749184],"study_design_scores_gemma":[0.5117587,0.4545642,0.02468278,0.00005699663,0.0006037165,0.0003658412,0.0000424321,0.0007666173,0.003846605,0.0001101306,0.003174902,0.00002719371],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912197,0.005798649,0.0005341308,0.0004431484,0.00009176256,0.0007328344,0.0002801737,0.00006449803,0.0008350452],"genre_scores_gemma":[0.9916146,0.003082897,0.001253666,0.001168697,0.0002626952,0.0006887135,0.0006858969,0.00001240724,0.001230482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002299581,"threshold_uncertainty_score":0.008838952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01014886927081247,"score_gpt":0.260049274401523,"score_spread":0.2499004051307105,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}