{"id":"W4386318621","doi":"10.1053/j.gastro.2023.08.038","title":"Guselkumab in Patients With Moderately to Severely Active Ulcerative Colitis: QUASAR Phase 2b Induction Study","year":2023,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University of British Columbia; McGill University Health Centre","funders":"Janssen Research and Development; Janssen Scientific Affairs","keywords":"Medicine; Placebo; Clinical endpoint; Internal medicine; Gastroenterology; Ulcerative colitis; Clinical trial; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001324848,0.0002056046,0.0001911386,0.0001711637,0.00007125801,0.0000174614,0.0001466405,0.00008888225,0.00001735114],"category_scores_gemma":[0.00003880524,0.0002005796,0.00003477894,0.0001501835,0.000052785,0.0000133168,0.0001237556,0.0001278957,0.00005577883],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006148888,"about_ca_system_score_gemma":0.00005509618,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002390762,"about_ca_topic_score_gemma":0.001567295,"domain_scores_codex":[0.998351,0.0003033697,0.0002292339,0.0005106828,0.0001517989,0.0004539191],"domain_scores_gemma":[0.9993504,0.000004796988,0.00007694921,0.0002885654,0.0001450749,0.0001342603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2361651,0.003358282,0.7496797,0.00001922139,0.0004252088,0.0003519023,0.002582663,0.002985299,0.00122302,0.00001350153,0.001948264,0.001247883],"study_design_scores_gemma":[0.008270945,0.00568589,0.9846597,0.000006635523,0.00001930656,0.000003124669,0.0006608668,0.00005283227,0.0004454864,0.00001098416,0.00006014667,0.0001240811],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983892,5.708154e-7,0.000144181,0.00008592667,0.0001391804,0.001046071,0.0001125515,0.00003260802,0.0000496661],"genre_scores_gemma":[0.998817,0.000001050493,0.0000511271,0.0003933582,0.00007062779,0.0002648069,0.0003053483,0.00003107101,0.00006558102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.23498,"threshold_uncertainty_score":0.8179396,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01014886927081247,"score_gpt":0.260049274401523,"score_spread":0.2499004051307105,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}