{"id":"W4386318869","doi":"10.1016/j.jaci.2023.07.022","title":"Intestinal microbiome and metabolome signatures in patients with chronic granulomatous disease","year":2023,"lang":"en","type":"article","venue":"Journal of Allergy and Clinical Immunology","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine; Hospital for Sick Children; University of Toronto; University of Calgary; Montreal Clinical Research Institute; Alberta Children's Hospital; Institute of Aging","funders":"NHLBI Division of Intramural Research; National Institute of Neurological Disorders and Stroke; National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Center for Advancing Translational Sciences; National Human Genome Research Institute; Government of South Australia; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; Canada Research Chairs; National Institutes of Health; Rare Diseases Clinical Research Network; Fonds de Recherche du Québec - Santé; University of South Florida; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; St. Baldrick's Foundation; Center for Cancer Research","keywords":"Metabolome; Microbiome; Chronic granulomatous disease; Inflammatory bowel disease; Immunology; Biology; Medicine; Medical microbiology; Disease; Internal medicine; Bioinformatics; Metabolomics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001426154,0.0002120701,0.0004268299,0.0004639735,0.0003271714,0.0004870577,0.0001272863,0.0004364621,0.001160285],"category_scores_gemma":[0.0008399228,0.0001098076,0.000236141,0.0005572014,0.0001870435,0.0003063803,0.0003711248,0.0003305874,0.0001299473],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001963724,"about_ca_system_score_gemma":0.0001375438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001320197,"about_ca_topic_score_gemma":0.001961918,"domain_scores_codex":[0.99985,0.000034509,0.00001899445,0.0000367598,0.00002200992,0.00003769536],"domain_scores_gemma":[0.9997062,0.00006263403,0.0001210839,0.00001168202,0.00003297857,0.00006536878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001298163,0.00005867052,0.9883413,0.00004886782,0.0001107124,0.0004328484,0.0001175142,0.00004627418,0.003817806,0.00002538643,0.0001851804,0.00551725],"study_design_scores_gemma":[0.00001117194,0.0001562965,0.998209,0.00001448275,0.00005299051,0.0007457539,0.0002168254,0.0001368521,0.0001501701,0.00004077674,0.0002614406,0.000004326566],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983268,0.0008958903,0.00004380967,0.00008308511,0.000008825671,0.000004959702,0.000264762,0.000003111648,0.0003687022],"genre_scores_gemma":[0.999331,0.0002028035,0.00006891415,0.00005557431,0.0000117183,0.000005324843,0.0002004989,0.000001501646,0.0001226666],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001320197,"threshold_uncertainty_score":0.003881574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01102748376219608,"score_gpt":0.2568328471813511,"score_spread":0.245805363419155,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}