{"id":"W4386319480","doi":"10.1016/s1473-3099(23)00343-2","title":"Safety, efficacy, and immunogenicity of a replication-defective human cytomegalovirus vaccine, V160, in cytomegalovirus-seronegative women: a double-blind, randomised, placebo-controlled, phase 2b trial","year":2023,"lang":"en","type":"article","venue":"The Lancet Infectious Diseases","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal","funders":"Merck Sharp and Dohme","keywords":"Medicine; Regimen; Placebo; Tolerability; Clinical endpoint; Population; Randomized controlled trial; Incidence (geometry); Internal medicine; Adverse effect; Pediatrics; Cytomegalovirus; Immunology; Viral disease; Human immunodeficiency virus (HIV); Herpesviridae","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00289065,0.0005540673,0.002374737,0.0009639858,0.0005363658,0.0001332016,0.0004085129,0.0002176412,0.000316718],"category_scores_gemma":[0.001549319,0.0004054974,0.0004632168,0.002121203,0.0004145468,0.0002560642,0.0003219471,0.000807927,0.0001257996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005670911,"about_ca_system_score_gemma":0.0004783442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001251325,"about_ca_topic_score_gemma":0.0005260856,"domain_scores_codex":[0.9952087,0.0006702078,0.001336839,0.0009604887,0.0007564973,0.001067266],"domain_scores_gemma":[0.9949176,0.002232109,0.0005621694,0.001559046,0.000315802,0.0004132454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.971984,0.002377552,0.01181519,0.0002089875,0.001265398,0.00006179153,0.001756884,0.0001044073,0.006796189,0.0004517756,0.0006638718,0.002513909],"study_design_scores_gemma":[0.9650339,0.002819811,0.02672975,0.0001431604,0.000454036,0.000036664,0.0003943418,0.0002435564,0.001212368,0.001202298,0.001311179,0.0004189335],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9835044,0.0008931993,0.00001533722,0.0005807061,0.0001342932,0.01061129,0.0003227281,0.0003987185,0.003539323],"genre_scores_gemma":[0.9932978,0.001306211,0.000005001009,0.0002643848,0.0006893749,0.003804669,0.0001458614,0.00008837219,0.0003983775],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01491456,"threshold_uncertainty_score":0.9998397,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04732195404534018,"score_gpt":0.3715243019577259,"score_spread":0.3242023479123857,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}