{"id":"W4386319480","doi":"10.1016/s1473-3099(23)00343-2","title":"Safety, efficacy, and immunogenicity of a replication-defective human cytomegalovirus vaccine, V160, in cytomegalovirus-seronegative women: a double-blind, randomised, placebo-controlled, phase 2b trial","year":2023,"lang":"en","type":"article","venue":"The Lancet Infectious Diseases","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal","funders":"Merck Sharp and Dohme","keywords":"Medicine; Regimen; Placebo; Tolerability; Clinical endpoint; Population; Randomized controlled trial; Incidence (geometry); Internal medicine; Adverse effect; Pediatrics; Cytomegalovirus; Immunology; Viral disease; Human immunodeficiency virus (HIV); Herpesviridae","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002196338,0.001713848,0.002815222,0.0003988517,0.0004156911,0.0009885912,0.001023292,0.003683595,0.004380601],"category_scores_gemma":[0.002859968,0.0008437571,0.00177677,0.0003654202,0.001721986,0.001168439,0.0003483265,0.00279918,0.0007444843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006229503,"about_ca_system_score_gemma":0.000824153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000683516,"about_ca_topic_score_gemma":0.0006139911,"domain_scores_codex":[0.9991075,0.0004934485,0.00005339082,0.0001546347,0.00006720443,0.0001238439],"domain_scores_gemma":[0.9987459,0.0005603639,0.0002396803,0.0001018701,0.00006872289,0.0002835121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9832965,0.004028262,0.0003717744,0.0004769157,0.0004612264,0.00002780795,0.00006443045,0.0001265702,0.003430688,0.00005464305,0.0002325081,0.007428549],"study_design_scores_gemma":[0.8814306,0.1161128,0.001175063,0.00002498637,0.0002650994,0.00002258372,0.00002056062,0.0001385111,0.0004279878,0.00009905454,0.000270229,0.00001256548],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922861,0.004280547,0.0003707302,0.0003629638,0.000345191,0.001150519,0.0004011173,0.00004489155,0.0007579416],"genre_scores_gemma":[0.9918097,0.002269068,0.0006530099,0.0006678023,0.0004223505,0.001826995,0.0005411077,0.00001896982,0.001790958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004380601,"threshold_uncertainty_score":0.01465464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04732195404534018,"score_gpt":0.3715243019577259,"score_spread":0.3242023479123857,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}