{"id":"W4386319516","doi":"10.1016/s2213-2600(23)00226-6","title":"Safety and efficacy of the epithelial sodium channel blocker idrevloride in people with primary ciliary dyskinesia (CLEAN-PCD): a multinational, phase 2, randomised, double-blind, placebo-controlled crossover trial","year":2023,"lang":"en","type":"article","venue":"The Lancet Respiratory Medicine","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; Montreal Children's Hospital","funders":"Vertex Pharmaceuticals","keywords":"Medicine; Primary ciliary dyskinesia; Double blind; Placebo; Crossover study; Pharmacology; Multinational corporation; Internal medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001796873,0.001963047,0.004788138,0.0003876952,0.0005331996,0.001194229,0.0009649916,0.003125649,0.005582762],"category_scores_gemma":[0.002381544,0.001053756,0.002541813,0.0003741063,0.001524452,0.001495929,0.0005363835,0.003635318,0.00101152],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007163747,"about_ca_system_score_gemma":0.0007536515,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001031048,"about_ca_topic_score_gemma":0.001756656,"domain_scores_codex":[0.999106,0.0003767117,0.00007320567,0.0002222531,0.00008101382,0.0001408363],"domain_scores_gemma":[0.9989531,0.0003515513,0.0002426165,0.00009293851,0.00008636992,0.0002734437],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9884096,0.002248009,0.0006409864,0.0005819763,0.001299425,0.00003022657,0.00004432641,0.00009009532,0.001402113,0.00004248218,0.0003277443,0.004882969],"study_design_scores_gemma":[0.9571114,0.03941999,0.001855178,0.00003708729,0.0009008514,0.00002144032,0.00002172659,0.0001250522,0.0001914886,0.0000643408,0.0002371093,0.00001426583],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9836189,0.01024586,0.0006032772,0.0005931069,0.0007301242,0.001770202,0.0008479045,0.0001034002,0.001487124],"genre_scores_gemma":[0.9895238,0.003369906,0.0009361116,0.001179349,0.0005644956,0.00187119,0.0008022253,0.00002367945,0.001729191],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005582762,"threshold_uncertainty_score":0.01867616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04436425798505699,"score_gpt":0.3479844628273109,"score_spread":0.3036202048422539,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}