{"id":"W4386323230","doi":"10.3390/curroncol30090583","title":"Genetic Variants in the Mitochondrial Thymidylate Biosynthesis Pathway Increase Colorectal Cancer Risk","year":2023,"lang":"en","type":"article","venue":"Current Oncology","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Genotype; Methylenetetrahydrofolate reductase; Thymidylate synthase; Colorectal cancer; Internal medicine; Allele; Medicine; Gastroenterology; Cytidine deaminase; Heterozygote advantage; Genetics; Oncology; Cancer; Biology; Gene; Fluorouracil","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003504194,0.0004353153,0.0003118181,0.0008258782,0.0003083786,0.00045456,0.0001966484,0.0006944077,0.001923002],"category_scores_gemma":[0.001352563,0.0003179529,0.0003344596,0.0005956134,0.0002062547,0.0001831504,0.0002003731,0.0003391039,0.0002383848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001627889,"about_ca_system_score_gemma":0.0001255368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002194369,"about_ca_topic_score_gemma":0.002371705,"domain_scores_codex":[0.9996516,0.0001023133,0.00003533163,0.0001022671,0.00005546627,0.00005315172],"domain_scores_gemma":[0.9992628,0.0002087426,0.0003278894,0.00005273865,0.0000512433,0.00009664702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008566998,0.0001079476,0.9886228,0.00002782773,0.0002171396,0.0004690866,0.00008815747,0.0000855988,0.005190684,0.00004738797,0.0000840938,0.004202554],"study_design_scores_gemma":[0.00003018162,0.0002955263,0.9970414,0.000006968024,0.0001224355,0.001341572,0.00005558899,0.0003557907,0.0004884193,0.00005861677,0.0001981256,0.000005406133],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999248,0.0003349093,0.0001108351,0.00002709168,0.000004093291,0.00000359248,0.00007051705,0.000005147708,0.0001960042],"genre_scores_gemma":[0.999519,0.0001135406,0.0001271071,0.0000120471,0.000007509972,0.000002041744,0.00007169897,0.00000180316,0.0001452313],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002194369,"threshold_uncertainty_score":0,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05665355029709671,"score_gpt":0.363043607827,"score_spread":0.3063900575299033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}