{"id":"W4386323720","doi":"10.1371/journal.pone.0290892","title":"Biochemical evidence that the whole compartment activity behavior of GAPDH differs between the cytoplasm and nucleus","year":2023,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Faculty of Medicine and Dentistry, University of Alberta; Canadian Institutes of Health Research; University of Alberta","keywords":"Glyceraldehyde 3-phosphate dehydrogenase; Cytoplasm; Biochemistry; Biology; Nucleus; Enzyme; Compartment (ship); Xenopus; Dehydrogenase; Cellular compartment; Allosteric regulation; Cell biology; Chemistry; Cell; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002271934,0.0002423324,0.0002180436,0.0002849265,0.0001800362,0.000546296,0.0002843146,0.0003461232,0.001177887],"category_scores_gemma":[0.0003833895,0.000198881,0.0002928053,0.0003351906,0.0003951442,0.0004603711,0.0002557286,0.0005069376,0.0005882504],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00030682,"about_ca_system_score_gemma":0.0003414296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001218516,"about_ca_topic_score_gemma":0.001464926,"domain_scores_codex":[0.999786,0.00002927204,0.0000159055,0.00009551238,0.0000437638,0.00002965041],"domain_scores_gemma":[0.99961,0.000110645,0.00008468834,0.00007393216,0.00007991565,0.00004073121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005938683,0.000006585586,0.0006735426,0.00003203964,0.00000670466,0.00003994107,0.00002911744,0.0000282497,0.9981047,0.0001179217,0.00002498395,0.000876833],"study_design_scores_gemma":[0.000008443708,0.0001847547,0.04834275,0.00001961432,0.00003402698,0.001063038,0.000149782,0.0008891133,0.9456565,0.0004013319,0.00323239,0.00001813405],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9484556,0.006036862,0.03812153,0.000435713,0.00009521939,0.00003823732,0.001509817,0.0003158568,0.004991233],"genre_scores_gemma":[0.9856122,0.001278864,0.008643124,0.0001720268,0.00002017081,0.0000382084,0.001395595,0.00007994649,0.002759928],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001218516,"threshold_uncertainty_score":0.003940403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1084440054167401,"score_gpt":0.2818834076978645,"score_spread":0.1734394022811245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}